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Contributions

Sequential investigation of aspartate aminotransferase elevation in outpatients

Frederick Van Lente, Ph.D., Robert S. Galen, M.D., William Castellani, M.D., David Chou, M.D. and Richard N. Matzen, M.D.
Cleveland Clinic Journal of Medicine May 1987, 54 (3) 171-175;
William R. Hart
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Frederick Van Lente
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Robert S. Galen
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William Castellani
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David Chou
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Richard N. Matzen
Department of Biochemistry and Preventive Medicine, The Cleveland Clinic Foundation
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ABSTRACT

The authors used a computer-based protocol to evaluate the significance of elevations in aspartate aminotransferase (AST) activity in outpatients undergoing periodic health examinations. The protocol was used to systematically guide the performance of confirming secondary tests when the initial AST activity was elevated. Interpretation of all laboratory results was computer generated by an EXPERT artificial intelligence program developed by the authors. Implementing this system in a laboratory-based accelerated testing program resulted in the investigation of 79 AST elevations in 3,096 outpatients; 93% of these results were confirmed by secondary testing and represented apparent alcohol-induced liver dysfunction, hepatitis (including HBV), unclassified liver dysfunction, muscle insult, or hypothyroidism. This laboratory testing protocol appears to be an attractive alternative to traditional laboratory screening.

Index terms
  • Decision making
  • computer-assisted
  • Pathology features
  • Received September 1986.
  • Accepted November 1986.
  • Copyright © 1987 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 54 (3)
Cleveland Clinic Journal of Medicine
Vol. 54, Issue 3
1 May 1987
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Sequential investigation of aspartate aminotransferase elevation in outpatients
Frederick Van Lente, Robert S. Galen, William Castellani, David Chou, Richard N. Matzen
Cleveland Clinic Journal of Medicine May 1987, 54 (3) 171-175;

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Sequential investigation of aspartate aminotransferase elevation in outpatients
Frederick Van Lente, Robert S. Galen, William Castellani, David Chou, Richard N. Matzen
Cleveland Clinic Journal of Medicine May 1987, 54 (3) 171-175;
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