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Contributions

Effect of oxygen on bleomycin-induced lung damage

Ramesh N. Sogal, MD, Alexandru A. Gottlieb, MD, Azmy R. Boutros, MD, Ram R. Ganapathi, PhD, Raymond R. Tubbs, MD, Patricia Satariano, CRNA, Paul R. Blakely, CRNA and Gerald J. Beck, PhD
Cleveland Clinic Journal of Medicine November 1987, 54 (6) 503-508;
Ramesh N. Sogal
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Alexandru A. Gottlieb
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Azmy R. Boutros
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Ram R. Ganapathi
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Raymond R. Tubbs
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Patricia Satariano
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Paul R. Blakely
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Gerald J. Beck
Division of Anesthesiology, The Cleveland Clinic Foundation
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ABSTRACT

Mortality and lung damage resulting from bleomycin-oxygen interaction were studied in mice. No animals died in the control group given saline and breathing 21% to 50% oxygen. Mortality following injection of 10 mg/kg and 20 mg/kg bleomycin, respectively, increased from 0% and 6% following exposure to 21% oxygen, to 20% and 33% after 30% oxygen, and to 47% and 66% after 50% oxygen. Pulmonary pathology also became progressively more severe at the higher oxygen concentrations as measured by pulmonary hydroxyproline content and a visually scored index of cellular pathology.

Index terms
  • Bleomycin
  • Lung
  • injury
  • Oxygen
  • Received October 1986.
  • Revision received June 1987.
  • Accepted January 1987.
  • Copyright © 1987 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 54 (6)
Cleveland Clinic Journal of Medicine
Vol. 54, Issue 6
1 Nov 1987
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Effect of oxygen on bleomycin-induced lung damage
Ramesh N. Sogal, Alexandru A. Gottlieb, Azmy R. Boutros, Ram R. Ganapathi, Raymond R. Tubbs, Patricia Satariano, Paul R. Blakely, Gerald J. Beck
Cleveland Clinic Journal of Medicine Nov 1987, 54 (6) 503-508;

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Effect of oxygen on bleomycin-induced lung damage
Ramesh N. Sogal, Alexandru A. Gottlieb, Azmy R. Boutros, Ram R. Ganapathi, Raymond R. Tubbs, Patricia Satariano, Paul R. Blakely, Gerald J. Beck
Cleveland Clinic Journal of Medicine Nov 1987, 54 (6) 503-508;
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Keywords

  • BLEOMYCIN
  • Lung
  • injury
  • Oxygen

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