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Cardiology Reviews

Recombinant t-PA and platelet activity

Richard C. Becker, MD
Cleveland Clinic Journal of Medicine September 1990, 57 (6) 537-541;
Richard C. Becker
Thrombosis Research Center, Division of Cardiology, University of Massachusetts Medical Center, Worcester.
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ABSTRACT

Platelet-rich coronary arterial occlusions are relatively resistant to thrombolysis with recombinant tissue-type plasminogen activator, or rt-PA, while erythrocyte-rich thrombi are lysed at low doses. The combined administration of rt-PA with a platelet antagonist enhances thrombolysis and can prevent reocclusion, which suggests that platelet activation predominates during thrombus formation and after thrombolysis. In addition to direct effects on platelet activity, rt-PA also acts indirectly through generation of plasmin, which degrades fibrin.

INDEX TERMS
  • Plasminogen Activator
  • Tissue-Type
  • Copyright © 1990 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 57 (6)
Cleveland Clinic Journal of Medicine
Vol. 57, Issue 6
1 Sep 1990
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Recombinant t-PA and platelet activity
Richard C. Becker
Cleveland Clinic Journal of Medicine Sep 1990, 57 (6) 537-541;

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Recombinant t-PA and platelet activity
Richard C. Becker
Cleveland Clinic Journal of Medicine Sep 1990, 57 (6) 537-541;
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