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Review

Experimental therapies for multiple sclerosis: current status

Donald E. Goodkin, MD, Richard M. Ransohoff, MD and Richard A. Rudick, MD
Cleveland Clinic Journal of Medicine January 1992, 59 (1) 63-74;
Donald E. Goodkin
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Richard M. Ransohoff
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Richard A. Rudick
Mellen Center for Multiple Sclerosis Treatment and Research, The Cleveland Clinic Foundation.
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ABSTRACT

Multiple sclerosis is the most common cause of nontraumatic disability affecting young adults in the United States. Its etiology remains unclear, but evidence points to alteration of normal immune system function in the pathogenesis of this illness. This article reviews the results of clinical trials of experimental therapeutic agents in multiple sclerosis. The background and action of each treatment are described, and the clinical experience with each agent is reviewed. Obstacles to evaluating the effectiveness of treatment methods in MS and challenges to the design of future clinical trials and the interpretation of trial outcomes are discussed.

INDEX TERMS
  • Multiple Sclerosis
  • Azathioprine
  • Polymers
  • Cyclophosphamide
  • Cyclosporins
  • Interferons
  • Plasmapheresis
  • Lymphatic Irradiation
  • Copyright © 1992 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine
Vol. 59, Issue 1
1 Jan 1992
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Experimental therapies for multiple sclerosis: current status
Donald E. Goodkin, Richard M. Ransohoff, Richard A. Rudick
Cleveland Clinic Journal of Medicine Jan 1992, 59 (1) 63-74;

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Experimental therapies for multiple sclerosis: current status
Donald E. Goodkin, Richard M. Ransohoff, Richard A. Rudick
Cleveland Clinic Journal of Medicine Jan 1992, 59 (1) 63-74;
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Keywords

  • Multiple Sclerosis
  • AZATHIOPRINE
  • Polymers
  • Cyclophosphamide
  • Cyclosporins
  • Interferons
  • Plasmapheresis
  • Lymphatic Irradiation

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