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Current Drug Therapy

Inhibitors of tumor necrosis factor: New treatment options for rheumatoid arthritis

Larry W. Moreland, MD
Cleveland Clinic Journal of Medicine June 1999, 66 (6) 367-374;
Donald G. Vidt
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Larry W. Moreland
Associate Professor of Medicine; Vice-Chairman for Clinical Research, Department of Medicine; Director, Arthritis Clinical Intervention Program; The University of Alabama at Birmingham; investigator in several clinical trials of etanercept.
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ABSTRACT

Infliximab and etanercept, both approved by the FDA in 1998, are examples of a new class of disease-modifying antirheumatic drugs that interfere with the action of tumor necrosis factor alpha, one of the key cytokines that promote inflammation. Infliximab is approved for Crohn disease and etanercept for rheumatoid arthritis. Both show promise in treating rheumatoid arthritis, although the long-term risks and benefits of these drugs are not yet known.

  • Copyright © 1999 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 66 (6)
Cleveland Clinic Journal of Medicine
Vol. 66, Issue 6
1 Jun 1999
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Inhibitors of tumor necrosis factor: New treatment options for rheumatoid arthritis
Larry W. Moreland
Cleveland Clinic Journal of Medicine Jun 1999, 66 (6) 367-374;

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Inhibitors of tumor necrosis factor: New treatment options for rheumatoid arthritis
Larry W. Moreland
Cleveland Clinic Journal of Medicine Jun 1999, 66 (6) 367-374;
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