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Cancer Diagnosis and Management

Human papillomavirus typing and the reduction of cervical cancer risk

Xian Wen Jin, MD, PhD, Joseph Cash, MD and Alexander W. Kennedy, MD
Cleveland Clinic Journal of Medicine October 1999, 66 (9) 533-539;
Maurie Markman
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Xian Wen Jin
Department of General Internal Medicine, Cleveland Clinic
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  • For correspondence: [email protected]
Joseph Cash
Chairman, Department of General Internal Medicine, Cleveland Clinic 'Deceased
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Alexander W. Kennedy
Cancer Center and Department of Gynecology and Obstetrics, Cleveland Clinic
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ABSTRACT

Minor cervical cytologic abnormalities are common, but knowing which low-grade lesions will progress to cervical cancer—and therefore deserve biopsy and excision—is difficult. Since some human papillomavirus (HPV) types are strongly associated with cervical cancer, HPV typing may be a means of determining which patients with minor abnormalities require biopsy and treatment and which need only follow-up smears. This paper reviews the association between cervical cancer and HPV infection, the pathogenesis of HPV infection, the utility of HPV typing in triaging patients with a diagnosis of atypical squamous cells of undetermined significance, and the prospects for the development of an HPV vaccine.

  • Copyright © 1999 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 66 (9)
Cleveland Clinic Journal of Medicine
Vol. 66, Issue 9
1 Oct 1999
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Human papillomavirus typing and the reduction of cervical cancer risk
Xian Wen Jin, Joseph Cash, Alexander W. Kennedy
Cleveland Clinic Journal of Medicine Oct 1999, 66 (9) 533-539;

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Human papillomavirus typing and the reduction of cervical cancer risk
Xian Wen Jin, Joseph Cash, Alexander W. Kennedy
Cleveland Clinic Journal of Medicine Oct 1999, 66 (9) 533-539;
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