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Medical Grand Rounds

Chronic myelogenous leukemia: The news you have and haven’t heard

Matt E. Kalaycio, MD
Cleveland Clinic Journal of Medicine November 2001, 68 (11) 913-926;
Matt E. Kalaycio
Director, Leukemia Program, Department of Hematology and Medical Oncology, The Cleveland Clinic
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ABSTRACT

Chronic myelogenous leukemia (CML) can usually be cured by bone marrow transplantation from matched donors. Donor T-cell activity from the graft is critical to maintaining remission. Myeloablation may not be necessary for cure. Non-myeloablative but immunosuppressive preparative regimens allow donor engraftment with less toxicity. Early combination therapy with interferon-alfa and cytarabine was the preferred option for patients who could not undergo bone marrow transplantation. Now, the advent of imatinib mesylate, a specific inhibitor of BCR/ABL tyrosine kinase, promises to change existing treatment paradigms

Footnotes

  • ↵* The author has indicated that he has received grant research support from Sangstat, Novartis, Genta, and Protein Design Labs, and that he is on the speakers bureau of Cell Therapeutics. This article discusses therapies that are not yet FDA-approved for the use under discussion and are investigational.

  • Copyright © 2001 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 68 (11)
Cleveland Clinic Journal of Medicine
Vol. 68, Issue 11
1 Nov 2001
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Chronic myelogenous leukemia: The news you have and haven’t heard
Matt E. Kalaycio
Cleveland Clinic Journal of Medicine Nov 2001, 68 (11) 913-926;

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Chronic myelogenous leukemia: The news you have and haven’t heard
Matt E. Kalaycio
Cleveland Clinic Journal of Medicine Nov 2001, 68 (11) 913-926;
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