Interpreting Key Trials

The STAR*D study: Treating depression in the real world

Bradley N. Gaynes, MD, MPH, A. John Rush, MD, Madhukar H. Trivedi, MD, Stephen R. Wisniewski, PhD, Donald Spencer, MD, MBA and Maurizio Fava, MD
Cleveland Clinic Journal of Medicine January 2008, 75 (1) 57-66;

ABSTRACT

The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut “winner,” it does provide guidance on how to start therapy and how to proceed if initial treatment fails.

Footnotes

  • ↵* The authors’ disclosures of potential conflicts of interest are listed at the end of this paper.

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