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Review

Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome

Chin Hee Kim, MD and Zobair M. Younossi, MD, MPH
Cleveland Clinic Journal of Medicine October 2008, 75 (10) 721-728;
Chin Hee Kim
Center for Liver Diseases–Inova Fairfax Hospital, Falls Church, VA
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Zobair M. Younossi
Center for Liver Diseases–Inova Fairfax Hospital, Falls Church, VA
Executive Director of Research, Inova Health System
Professor of Medicine, Virginia Commonwealth University, Inova Campus
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  • For correspondence: zobair.younossi@inova.com
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ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) has become the most common form of liver disease, affecting 20% to 30% of the US population. Its clinical manifestations are usually absent or subtle, and it usually comes to medical attention incidentally when aminotransferase levels are found to be elevated or a radiographic study reveals that the liver is fatty. Primary NAFLD is now considered the hepatic manifestation of the metabolic syndrome. The pathogenesis is thought to be a multiple-hit process involving insulin resistance, oxidative stress, apoptosis, and adipokines. In general, the prognosis for simple steatosis is very good; however, nonalcoholic steatohepatitis (NASH) can progress to cirrhosis and hepatocellular carcinoma in 10% to 15% of patients. There is no established treatment for NAFLD except for weight loss and treating each component of the metabolic syndrome.

Footnotes

  • ↵* Dr. Younossi has disclosed that he has received honoraria from Chronic Liver Disease Communications, Clinical Care Options, and Medscape for CME presentations.

  • Copyright © 2008 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 75 (10)
Cleveland Clinic Journal of Medicine
Vol. 75, Issue 10
1 Oct 2008
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Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome
Chin Hee Kim, Zobair M. Younossi
Cleveland Clinic Journal of Medicine Oct 2008, 75 (10) 721-728;

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Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome
Chin Hee Kim, Zobair M. Younossi
Cleveland Clinic Journal of Medicine Oct 2008, 75 (10) 721-728;
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