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Cleveland Clinic Journal of Medicine

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Table of Contents

October 01, 2008; Volume 75,Issue 10

From the Editor

  • You have access
    When a quick sound bite won’t do
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 686;

    In the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, why did more patients die if they got intensive therapy than if they got standard therapy? In this issue of the Journal, an investigator in this trial gives his analysis.

The Clinical Picture

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    A judgment call
    Deepak Asudani, MD, Sharon Wretzel, MD, Ruchita Patel, MD and Aaron Stayman, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 690-695;

    A young man hospitalized because of a sickle cell crisis requires a central venous line. However, after the catheter is inserted, an initial chest radiograph reveals that the tip may not be in the right place. What should be done?

Editorial

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    Preventing renal disease progression: Can complete renin-angiotensin- aldosterone blockade work?
    Martin J. Schreiber, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 699-704;

    In view of the risks of complete blockade of the renin-angiotensin- aldosterone pathway, more data from clinical trials are needed before the general medical community widely applies this strategy to prevent progressive chronic kidney disease.

Review

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    An update on proteinuric chronic kidney disease: The dual-goal approach
    Sheldon Hirsch, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 705-713;

    To slow the progression of proteinuric chronic kidney disease, we may need to set goals for lowering both blood pressure and urinary albumin excretion, using drugs that block the renin-angiotensin-aldosterone system at multiple sites or in higher doses. However, this dual-goal approach needs to be validated prospectively.

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    Which patients benefit from carotid stenting? What recent trials show
    Mark Bain, MD, Asma M. Moheet, MD and Peter Rasmussen, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 714-720;

    Whether carotid stenting has any advantage over carotid surgery and which patients should undergo it are still topics of study and debate.

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    Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome
    Chin Hee Kim, MD and Zobair M. Younossi, MD, MPH
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 721-728;

    As we get heavier, our livers get fattier. Despite an explosion of research on nonalcoholic fatty liver disease and gains in understanding its epidemiology and pathogenesis, a number of issues remain unresolved, including how to treat it.

Interpreting Key Trials

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    A Clinician and Clinical Trialist’s Perspective
    Byron J. Hoogwerf, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 729-737;

    Even though more people died in the intensive-treatment group than in the standard-treatment group, the results from this trial should not substantially alter our usual approach to glucose-lowering.

Review

  • Using biochemical markers of bone turnover in clinical practice
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    Using biochemical markers of bone turnover in clinical practice
    Frederick R. Singer, MD and David R. Eyre, PhD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 739-750;

    Although no guidelines to date recommend the widespread use of these markers in clinical practice, we believe they will eventually be accepted.

Editorial

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    Biochemical markers of bone turnover: Useful but underused
    Angelo A. Licata, MD
    Cleveland Clinic Journal of Medicine October 2008, 75 (10) 751-752;

    Markers tell us the risk of fracture and are useful in patient management. But will insurance pay for testing?

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In this issue

Cleveland Clinic Journal of Medicine: 75 (10)
Cleveland Clinic Journal of Medicine
Vol. 75, Issue 10
1 Oct 2008
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The beat goes on: Highlights from the new American and European A-fib guidelines
What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?
Tinea incognito
Prolonged venous filling time and dependent rubor in a patient with peripheral artery disease
Nociplastic pain: A practical guide to chronic pain management in the primary care setting
Sarcoidosis with diffuse purplish erythematous plaques on the hands
Cardiovascular disease in people living with HIV: Risk assessment and management
Heart to heart: Progress in cardiovascular disease prevention for people living with HIV
Don’t judge a book by its cover: Unusual presentations of pericardial disease
Hypoglycemia after bariatric surgery: Management updates
Risk-factor modification to prevent recurrent atrial fibrillation after catheter ablation
Common electrolyte imbalance, uncommon cause

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