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1-Minute Consult

When does chest CT require contrast enhancement?

Camila Piza Purysko, MD, Rahul Renapurkar, MD and Michael A. Bolen, MD
Cleveland Clinic Journal of Medicine June 2016, 83 (6) 423-426; DOI: https://doi.org/10.3949/ccjm.83a.15037
Camila Piza Purysko
Imaging Institute, Cleveland Clinic
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Rahul Renapurkar
Imaging Institute, Cleveland Clinic
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Michael A. Bolen
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  • FIGURE 1
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    FIGURE 1

    In a patient with colon cancer undergoing a workup for metastases, axial CT without contrast (A) shows prominence of the right hilar region (arrow). Axial CT with contrast enhancement obtained subsequently (B and C) shows that this abnormality corresponds to right hilar lymphadenopathy partially encasing the right pulmonary artery (arrows).

  • FIGURE 2
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    FIGURE 2

    In a 79-year-old patient with chronic thromboembolic pulmonary hypertension, CT angiography of the pulmonary artery (A) shows weblike (red arrow) and partially calcified filling defects (yellow arrow), as well as diffuse mild mosaic attenuation of lung parenchyma (B).

  • FIGURE 3
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    FIGURE 3

    CT pulmonary angiography with intravenous contrast in a patient being evaluated for arteriovenous malformation. Maximum-intensity projection images reconstructed in the axial (A) and coronal (B) planes show bilateral arteriovenous malformations with corresponding feeding arteries (white arrows) and draining veins (black arrows).

  • FIGURE 4
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    FIGURE 4

    CT without contrast in a patient with a history of interstitial lung disease and right lung transplant shows the patent but partially narrowed anastomotic site of the right bronchus (A) (red arrow). In B, the native left lung is small, with evidence of bronchiectasis, bronchiolectasis, and areas of honeycombing (black arrow). In C, the transplanted lung is notable for areas of air trapping in the right upper lobe on expiratory images (blue arrow), which is associated with central airway narrowing.

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    TABLE 1

    Computed tomography (CT) with and without contrast: indications and protocols

    Intravenous contrast required
    Malignancy workup and follow-up may require contrast to delineate hila, chest wall, vascular margins, or recurrent or residual tumor
    CT pulmonary angiography for pulmonary embolism
    CT pulmonary venography for superior vena cava syndrome
    CT pulmonary angiography for arteriovenous malformation Suspected or known malignancy or infection of chest wall or mediastinum
    Intravenous contrast usually not required
    Solitary pulmonary nodule a
    Lung screening with low-dose CT
    Pulmonary parenchyma, to evaluate for infection, inflammation, edema
    Interstitial lung diseaseb
    Pleural effusionc
    Airway assessment
    • ↵a However, contrast enhancement may help identify tumors such as carcinoid and may better highlight internal morphology. Dynamic enhancement is also occasionally performed.

    • ↵b Tailored protocol uses thinner slices and expiratory images to evaluate for air-trapping and dynamic airway compromise.

    • ↵c Contrast is required to evaluate for empyema and suspected or known pleural malignancy.

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Cleveland Clinic Journal of Medicine: 83 (6)
Cleveland Clinic Journal of Medicine
Vol. 83, Issue 6
1 Jun 2016
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When does chest CT require contrast enhancement?
Camila Piza Purysko, Rahul Renapurkar, Michael A. Bolen
Cleveland Clinic Journal of Medicine Jun 2016, 83 (6) 423-426; DOI: 10.3949/ccjm.83a.15037

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When does chest CT require contrast enhancement?
Camila Piza Purysko, Rahul Renapurkar, Michael A. Bolen
Cleveland Clinic Journal of Medicine Jun 2016, 83 (6) 423-426; DOI: 10.3949/ccjm.83a.15037
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    • EVALUATION OF SUSPECTED CANCER
    • EVALUATION OF THORACIC VASCULAR DISEASE
    • EVALUATION OF PULMONARY PARENCHYMAL DISEASE
    • EVALUATION OF THE PLEURA
    • EVALUATION OF AIRWAY DISEASE
    • EVALUATION OF STERNAL AND MEDIASTINAL INFECTIONS
    • TYPES OF IV CONTRAST MEDIA
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