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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Nephrology

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    Hematochezia in a patient with end-stage renal disease
    Brennan Gioe, MD, Conrad Fernandes, MD, E. Celia Marginean, MD and Stalin Subramanian, MD
    Cleveland Clinic Journal of Medicine June 2026, 93 (6) 333-338; DOI: https://doi.org/10.3949/ccjm.93a.25097

    The patient developed gastrointestinal bleeding after being started on intravenous heparin following thrombectomy and angioplasty for acute limb ischemia.

  • Managing chronic kidney disease according to KDIGO risk categories: A primer for primary care
    You have access
    Managing chronic kidney disease according to KDIGO risk categories: A primer for primary care
    Rodolfo J. Galindo, MD, Diana Soliman, MD, Joshua J. Neumiller, PharmD, Jay H. Shubrook, DO and Katherine R. Tuttle, MD
    Cleveland Clinic Journal of Medicine June 2026, 93 (6) 353-365; DOI: https://doi.org/10.3949/ccjm.93a.25072

    The authors review the KDIGO guideline updates and provide a simplified treatment algorithm for non-nephrologists, focusing on medication sequencing and monitoring.

  • You have access
    KDIGO chronic kidney disease heat map: Let the colors be your guide!
    Crystal Gadegbeku, MD
    Cleveland Clinic Journal of Medicine June 2026, 93 (6) 366-367; DOI: https://doi.org/10.3949/ccjm.93a.26017

    Clinicians need to adopt early interventions that can alter the course of chronic kidney disease for patients.

  • You have access
    Finding the cause of severe hypokalemia
    Philip S. Mehler, MD and Dennis Gibson, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198; DOI: https://doi.org/10.3949/ccjm.93c.04001
  • You have access
    In Reply: Finding the cause of severe hypokalemia
    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198; DOI: https://doi.org/10.3949/ccjm.93c.04002
  • You have access
    Complement inhibition: A whole new world
    Nicholas Salupo, DO, Korey Bartolomeo, DO, Elias Bassil, MD, Corey Cavanaugh, DO, Georges Nakhoul, MD, MEd, Jonathan Taliercio, DO and Ali Mehdi, MD, MEd
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 227-236; DOI: https://doi.org/10.3949/ccjm.93a.25076

    As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.

  • You have access
    Clinical application of the complement system: A historical perspective
    Adam J. Brown, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239; DOI: https://doi.org/10.3949/ccjm.93a.26014

    Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • You have access
    Rapidly progressive kidney failure in an 82-year-old man with respiratory symptoms
    CME article
    Bernardo Henrique Mendes Correa, MD, Ali Mushtaq, MD, Ali Awada, Faiz Anwer, MD and Anam Ashfaque, MD
    Cleveland Clinic Journal of Medicine February 2026, 93 (2) 99-105; DOI: https://doi.org/10.3949/ccjm.93a.25037

    The patient presented to the emergency department due to worsening dry cough, lower-extremity edema, and fatigue, all of which had begun about 2 weeks earlier.

  • You have access
    Cystatin C for estimating glomerular filtration rate and guiding medication dosing
    Shahzeb Saeed, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 722-723; DOI: https://doi.org/10.3949/ccjm.92c.12004
  • Finding the cause of severe hypokalemia: A 4-step approach
    You have access
    Finding the cause of severe hypokalemia: A 4-step approach
    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 748-756; DOI: https://doi.org/10.3949/ccjm.92a.25055

    This case illustrates the approach to a group of conditions associated with hypokalemia that usually pose a diagnostic challenge.

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