Article Figures & Data
Figures
- FIGURE 1
Prognosis of chronic kidney disease (CKD) by glomerular filtration rate (GFR) and albuminuria.
- FIGURE 2
Risk for all-cause and major cause-specific death in black vs white patients.
Adapted from Navaneethan SD, Schold JD, Arrigain S, Jolly SE, Nally JV Jr. Cause-specific deaths in non-dialysis-dependent CKD. J Am Soc Nephrol 2015; 26:2512–2520.
- FIGURE 3
Variants in the APOL1 gene that are common in sub-Saharan Africa protect against African sleeping sickness, but homozygosity for these variants increases the risk of chronic kidney disease.
- FIGURE 4
Proportion of patients free from progression of chronic kidney disease, according to APOL1 genotype, in the African American Study of Kidney Disease and Hypertension. The primary outcome was reduction in the glomerular filtration rate (as measured by iothalamate clearance) or incident end-stage renal disease.
From Parsa A, Kao WH, Xie D, et al; AASK Study Investigators; CRIC Study Investigators. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med 2013; 369:2183–2196. Reprinted with permission from Massachusetts Medical Society.
Tables
Cause of death, n (%) Overall (n = 6,661) eGFR 45–59 (n = 3,308) eGFR 30–44 (n = 2,261) eGFR < 30 (n = 1,092) Cardiovascular disease 2,311 (34.7) 1,017 (30.7) 862 (38.1) 432 (39.6) Ischemic heart disease 1,227 (18.4) 532 (16.1) 457 (20.2) 238 (21.8) Heart failure 163 (2.4) 61 (1.8) 75 (3.3) 27 (2.5) Cerebrovascular disease 255 (3.8) 123 (3.7) 94 (4.2) 38 (3.5) Other cardiovascular disease 666 (10.0) 301 (9.1) 236 (10.4) 129 (11.8) Malignant neoplasm 2,117 (31.8) 1,282 (38.8) 616 (27.2) 219 (20.1) Other cause 2,233 (33.5) 1,009 (30.5) 783 (34.7) 441 (40.3) eGFR = estimated glomerular filtration rate
Adapted from reference 9.
