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Cardiology Tall Rounds

Cardiogenic shock: From ECMO to Impella and beyond

Mehdi H. Shishehbor, DO, MPH, PhD, Nader Moazami, MD, Michael Z.-Y. Tong, MD, MBP, Shinya Unai, MD, W. H. Wilson Tang, MD and Edward G. Soltesz, Md, MPH
Cleveland Clinic Journal of Medicine April 2017, 84 (4) 287-295; DOI: https://doi.org/10.3949/ccjm.84gr.17002
Mehdi H. Shishehbor
Medical Director, Endovascular Services, Department of Cardiovascular Medicine, and Associate Program Director, Interventional Cardiology, Heart and Vascular Institute, Cleveland Clinic
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  • For correspondence: [email protected]
Nader Moazami
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Michael Z.-Y. Tong
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
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Shinya Unai
Clinical Associate, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic
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W. H. Wilson Tang
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Edward G. Soltesz
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  • Article
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  • FIGURE 1
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    FIGURE 1

    In one configuration of venoarterial extracorporeal membrane oxygenation (ECMO), blood is removed from the inferior vena cava, a centrifugal pump passes it over a membrane oxygenator, and it is ejected into the aorta.

  • FIGURE 2
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    FIGURE 2

    An intra-aortic balloon pump (lABP) deflates at the beginning of systole (left) and inflates at the beginning of diastole (right), increasing coronary perfusion and reducing left ventricular afterload.

  • FIGURE 3
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    FIGURE 3

    The Impella device withdraws blood from the left ventricle and ejects it into the ascending aorta.

  • FIGURE 4
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    FIGURE 4

    The TandemHeart intake catheter is inserted through the venous circulation and across the atrial septum into the left atrium.

  • FIGURE 5
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    FIGURE 5

    The Impella RP removes blood from the inferior vena cava and ejects it into the pulmonary artery.

Tables

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    TABLE 1

    Criteria for receiving left ventricular assist devices as destination therapy

    Centers for Medicare and Medicaid Services Criteria
    New York Heart Association class IV (severe limitations)
    Intra-aortic balloon pump (> 7 days) (or peak VO2 < 14 mL/kg/min)
    No response to medical therapy
    Left ventricular ejection fraction < 25%
    Adequate right ventricular function
    Major contraindications to heart transplant
    Smoking cessation < 6 months
    Substance dependency
    Inadequate decision-making capacity
    Irreversible pulmonary hypertension (> 5 Wood units)
    Psychosocial issues
    Other end-organ issues
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    TABLE 2

    Options for short-term circulatory support

    IABPTandemHeartImpella 2.5Impella CP, 5.0ECMOCentriMag
    Circulatory support15%30%–60%30%–60%75%–100%75%–100%75%–100%
    InsertionPercutaneousPercutaneous, septal puncturePercutaneousArterial accessPercutaneousSternotomy
    • ECMO = extracorporeal membrane oxygenation; IABP = intra-aortic balloon pump

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    TABLE 3

    Right ventricular assist devices

    ECMO RotaflowCentriMag Ventricular Assist SystemImpella RP
    Cannulation inflowPulmonary arteryPulmonary arterySingle cannula
    Cannulation outflowFemoral vein, right atriumFemoral vein, right atriumSingle cannula
    Ease of insertionEasyEasyMore difficult
    InsertionSternotomySternotomyPercutaneous
    Cost$$$$$$
    BiocompatibilityCompatibleVery compatibleCompatible
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Cleveland Clinic Journal of Medicine: 84 (4)
Cleveland Clinic Journal of Medicine
Vol. 84, Issue 4
1 Apr 2017
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Cardiogenic shock: From ECMO to Impella and beyond
Mehdi H. Shishehbor, Nader Moazami, Michael Z.-Y. Tong, Shinya Unai, W. H. Wilson Tang, Edward G. Soltesz
Cleveland Clinic Journal of Medicine Apr 2017, 84 (4) 287-295; DOI: 10.3949/ccjm.84gr.17002

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Cardiogenic shock: From ECMO to Impella and beyond
Mehdi H. Shishehbor, Nader Moazami, Michael Z.-Y. Tong, Shinya Unai, W. H. Wilson Tang, Edward G. Soltesz
Cleveland Clinic Journal of Medicine Apr 2017, 84 (4) 287-295; DOI: 10.3949/ccjm.84gr.17002
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Jump to section

  • Article
    • ABSTRACT
    • ACUTE CARDIOGENIC SHOCK
    • CASE REVISITED
    • CATHETERIZATION LABORATORY DEVICE CAPABILITIES
    • CHOOSING AMONG PERCUTANEOUS DEVICES
    • SHORT-TERM CIRCULATORY SUPPORT: ECMO, IMPELLA, TANDEMHEART
    • DEVICES FOR RIGHT-SIDED SUPPORT
    • CASE REVISITED
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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