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Review

Maternal asthma: Management strategies

Sucharita Kher, MD, FCCP and Prerna Mota, MD
Cleveland Clinic Journal of Medicine April 2017, 84 (4) 296-302; DOI: https://doi.org/10.3949/ccjm.84a.15046
Sucharita Kher
Assistant Professor of Medicine, Tufts University School of Medicine; Medical Director, Pulmonary Clinic, Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, MA
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  • For correspondence: [email protected]
Prerna Mota
Pulmonary and Critical Care Medicine, Lawrence General Hospital, Lawrence, MA
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    TABLE 1

    Uncontrolled asthma in pregnancy: Effects on mother and fetus

    Maternal effects
    Preeclampsia
    Pregnancy-induced hypertension
    Gestational diabetes
    Premature rupture of membranes
    Cesarean birth
    Chorioamnionitis
    Hyperemesis
    Postpartum hemorrhage
    Fetal effects
    Perinatal death
    Preterm birth
    Low birth weight
    Intrauterine growth restriction
    Congenital malformations
    Admission to neonatal intensive care unit
    Hyperbilirubinemia
    Respiratory distress syndrome
    Transient tachypnea of the newborn
    Asphyxia
    Increased risk of intracerebral hemorrhage, anemia
    • Based in part on information in reference 9.

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    TABLE 2

    A definition of asthma control

    Minimal or no chronic symptoms day or night
    Minimal or no exacerbations
    No limitation on activities
    Maintenance of normal or near-normal pulmonary function
    Minimal use of short-acting beta-agonists
    Minimal or no adverse effects from medications
    • Based on information in reference 12.

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    TABLE 3

    Drug therapy of maternal asthma: Former pregnancy risk categories

    DrugCategorya
    Short-acting beta-agonist
    AlbuterolC
    Long-acting beta-agonists
    FormoterolC
    SalmeterolC
    Inhaled corticosteroids
    Budesonide (inhalation)B
    Fluticasone (inhalation)C
    Leukotriene modifiers
    Montelukast, zafirlukastB
    ZileutonC
    Monoclonal antibody
    OmalizumabB
    Xanthine derivative
    TheophyllineC
    Intranasal corticosteroids
    Intranasal budesonideB
    Intranasal fluticasoneC
    Intranasal mometasoneC
    Intranasal triamcinoloneC
    • ↵a Former US Food and Drug Administration risk category (see Drugs, this page).

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    TABLE 4

    Management of asthma exacerbations in pregnancy

    Monitor to ensure the maternal oxygen saturation remains above 95%
    Consider systemic (oral) corticosteroids
    Administer rescue therapy with a short-acting beta-agonist
    Consider hospital admission if symptoms do not improve with emergency room care
    Consider admission to intensive care unit and mechanical ventilation if symptoms are severe or if patient shows signs of impending respiratory failure
    Carefully monitor fetal health
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Cleveland Clinic Journal of Medicine: 84 (4)
Cleveland Clinic Journal of Medicine
Vol. 84, Issue 4
1 Apr 2017
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Maternal asthma: Management strategies
Sucharita Kher, Prerna Mota
Cleveland Clinic Journal of Medicine Apr 2017, 84 (4) 296-302; DOI: 10.3949/ccjm.84a.15046

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Maternal asthma: Management strategies
Sucharita Kher, Prerna Mota
Cleveland Clinic Journal of Medicine Apr 2017, 84 (4) 296-302; DOI: 10.3949/ccjm.84a.15046
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  • Article
    • ABSTRACT
    • EFFECT OF PREGNANCY ON ASTHMA CONTROL
    • EFFECT OF ASTHMA ON MATERNAL AND FETAL OUTCOMES
    • OUTPATIENT MANAGEMENT OF MATERNAL ASTHMA
    • MANAGEMENT OF SPECIFIC TRIGGERS
    • ROLES OF CONTROLLER THERAPY AND RESCUE THERAPY
    • ACUTE EXACERBATIONS REQUIRE AGGRESSIVE MANAGEMENT
    • REFERENCES
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