ABSTRACT
Critically ill patients are at an increased risk for developing stress ulcers of the mucosa of the upper gastrointestinal (GI) tract. Bleeding from stress ulcers was previously associated with a longer stay in the intensive care unit and an increased risk of death. Thus, most patients admitted to the intensive care unit receive stress ulcer prophylaxis. However, there is a growing concern that acid-suppression drugs may be associated with increased frequency of nosocomial pneumonia and Clostridioides difficile infection. In this article, the authors address controversies regarding stress ulcer prophylaxis in critically ill patients and provide guidance for its appropriate use in this setting.
- Copyright © 2022 The Cleveland Clinic Foundation. All Rights Reserved.
- Mariam Saeed, MD⇑
- Address:
Mariam Saeed, MD, Respiratory Institute, A90, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; saeedm{at}ccf.org
- Stephanie Bass, PharmD
- Neal F. Chaisson, MD
ABSTRACT
Critically ill patients are at an increased risk for developing stress ulcers of the mucosa of the upper gastrointestinal (GI) tract. Bleeding from stress ulcers was previously associated with a longer stay in the intensive care unit and an increased risk of death. Thus, most patients admitted to the intensive care unit receive stress ulcer prophylaxis. However, there is a growing concern that acid-suppression drugs may be associated with increased frequency of nosocomial pneumonia and Clostridioides difficile infection. In this article, the authors address controversies regarding stress ulcer prophylaxis in critically ill patients and provide guidance for its appropriate use in this setting.
- Copyright © 2022 The Cleveland Clinic Foundation. All Rights Reserved.
In this issue
Jump to section
- Article
- ABSTRACT
- WHICH PATIENTS ARE AT INCREASED RISK?
- WHAT IS THE EFFECT OF STRESS ULCER PROPHYLAXIS ON OUTCOMES?
- WHICH AGENT SHOULD I USE?
- DOES ENTERAL NUTRITION REDUCE THE RISK OF DEVELOPING STRESS ULCERS?
- WHAT IS THE OPTIMAL DURATION OF STRESS ULCER PROPHYLAXIS IN ICU PATIENTS?
- THE BOTTOM LINE
- DISCLOSURES
- REFERENCES
- Figures & Data
- Info & Metrics
Related Articles
Cited By...
- No citing articles found.