Gastroenterology
- Newer diabetes drugs: Surprising shared benefits and unique side effects
The shared beneficial effects of the SGLT2 inhibitors and the GLP-1 receptor agonists, drugs with distinct mechanisms of action, may have an anti-inflammatory explanation.
- Glucagon-like peptide-1 receptor agonists and pancreatitis: A reconcilable divorce
Early trials suggested a link between GLP-1 receptor agonists and pancreatitis, but recent large meta-analyses do not support a class-wide risk.
- Immunotherapy meets William Shakespeare
Immune checkpoint inhibitors are potentially life-saving therapies that can trigger a wide range of autoimmune pathology.
- How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy?
Diarrhea and colitis, which can result from infection or be complications of immune checkpoint inhibitors, require prompt evaluation so that appropriate treatment can be started.
Fecal microbiota transplantation: Current evidence and future directionsFecal microbiota transplantation is recognized for effectively treating recurrent Clostridioides difficile infection, prompting further investigation into its other possible clinical applications.
- Which patients with presumed acute infectious diarrhea in an outpatient setting should undergo gastrointestinal pathogen panel testing?
Use of a gastrointestinal pathogen panel is warranted in certain individuals, such as those with fever, visible blood in the stool, sepsis, or a compromised immune system.
- Abdominal pain in a patient with epistaxis, telangiectasias, and arteriovenous malformations
The pain was radiating to the back, exacerbated by eating, and accompanied by intermittent nausea and fatigue.
- Treatment of H pylori infection
In the August 2024 issue, the article “Helicobacter pylori: A concise review of the latest treatments against an old foe” by Aldhaleei WA, Wallace MB, Harris DM, Bi Y [Cleve Clin J Med 2024; 91(8):481–487; doi:10.3949/ccjm.91a.24031] contained an error in the first paragraph of the section titled “Proton pump inhibitor or potassium-competitive acid blockers” (pages 484–485).
- Mesenteric ischemia: Recognizing an uncommon disorder and distinguishing among its causes
Mesenteric ischemia is associated with high mortality and often poses a diagnostic challenge. Early recognition and diagnosis are imperative to improve outcomes.
