Functional dyspepsia: How to manage the burn and the bloat

Article Figures & Data

TABLE 1

Effect of various treatments on functional dyspepsia

Treatment^a	Effect on postprandial distress^b	Effect on epigastric pain^b
Antisecretory agents
Famotidine¹⁷	++ ++
Proton pump inhibitors^10,20	++ ++
Neuromodulators
Buspirone^23,24	++	0
Mirtazapine²⁵	++	0
Amitriptyline²⁶	0	++
Escitalopram²⁶	0	+
Gabapentin²⁷	+	NA
Pregabalin²⁸	++	++
Prokinetic therapy
Metoclopramide²⁹	++	++
Antibiotics
Rifaximin³⁰	++	++
Complementary and alternative medicine
STW 5³¹	NA	NA
Caraway and L-menthol³²	++	++
Capsaicin³³	++	++
Acupuncture³⁴	+	+
Hypnotherapy³⁵	NA	+

↵a All treatments are off-label. No treatment for functional dyspepsia has yet been approved by the US Food and Drug Administration.
↵b Qualitative estimates of effect are based on experience and the studies summarized in the text: 0 = no effect, + = some effect, ++ = moderate effect, +++ = strong effect.
NA = information not available