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Review

Psychedelic-assisted therapy: An overview for the internist

Brian S. Barnett, MD, Erin E. Mauney, MD and Franklin King, MD
Cleveland Clinic Journal of Medicine March 2025, 92 (3) 171-180; DOI: https://doi.org/10.3949/ccjm.92a.24032
Brian S. Barnett
Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Principal investigator, Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD , and A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (VOYAGE)
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Erin E. Mauney
Researcher, Center for Neurointestinal Health, Massachusetts General Hospital Division of Gastroenterology, Boston, MA; Assistant Professor, Pediatric Gastroenterology, Tufts Medical Center, Boston, MA; Co-investigator, Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
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Franklin King IV
Director, Training and Education, Center for Neuroscience of Psychedelics, Massachusetts General Hospital, Boston, MA; Instructor, Department of Psychiatry, Harvard Medical School, Boston, MA; Principal investigator, Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
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Article Information

vol. 92 no. 3 171-180
DOI 
https://doi.org/10.3949/ccjm.92a.24032
PubMed 
40032306

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online March 3, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Brian S. Barnett, MD⇑
  1. Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Principal investigator, Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD NCT05711940, and A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (VOYAGE) NCT06741228
  1. Address:
    Brian S. Barnett, MD, Department of Psychiatry and Psychology, Cleveland Clinic, 1730 West 25th Street 5E, Cleveland, OH 44113; barnetb3{at}ccf.org
  1. Erin E. Mauney, MD
  1. Researcher, Center for Neurointestinal Health, Massachusetts General Hospital Division of Gastroenterology, Boston, MA; Assistant Professor, Pediatric Gastroenterology, Tufts Medical Center, Boston, MA; Co-investigator, Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS) NCT06206265
  1. Franklin King IV, MD
  1. Director, Training and Education, Center for Neuroscience of Psychedelics, Massachusetts General Hospital, Boston, MA; Instructor, Department of Psychiatry, Harvard Medical School, Boston, MA; Principal investigator, Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS) NCT06206265

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Cleveland Clinic Journal of Medicine: 92 (3)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 3
1 Mar 2025
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Psychedelic-assisted therapy: An overview for the internist
Brian S. Barnett, Erin E. Mauney, Franklin King
Cleveland Clinic Journal of Medicine Mar 2025, 92 (3) 171-180; DOI: 10.3949/ccjm.92a.24032

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Psychedelic-assisted therapy: An overview for the internist
Brian S. Barnett, Erin E. Mauney, Franklin King
Cleveland Clinic Journal of Medicine Mar 2025, 92 (3) 171-180; DOI: 10.3949/ccjm.92a.24032
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  • Article
    • ABSTRACT
    • OVERVIEW OF PSYCHEDELICS
    • HISTORICAL PERSPECTIVE
    • PSYCHEDELIC-ASSISTED THERAPY PARADIGM
    • MDMA-ASSISTED THERAPY FOR PTSD
    • PSILOCYBIN-ASSISTED THERAPY FOR DEPRESSION
    • POST–REGULATORY APPROVAL CONSIDERATIONS
    • NONPSYCHIATRISTS’ ROLE IN PSYCHEDELIC-ASSISTED THERAPY
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