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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Drug Therapy

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    Insomnia in older adults
    Anup Katyal, MD
    Cleveland Clinic Journal of Medicine March 2025, 92 (3) 143-144; DOI: https://doi.org/10.3949/ccjm.92c.03004
  • You have access
    In Reply: Insomnia in older adults
    Margaret M. Chaplain, MD, Roberto León-Barriera, MD and Vania Modesto-Lowe, MD, MPH
    Cleveland Clinic Journal of Medicine March 2025, 92 (3) 144; DOI: https://doi.org/10.3949/ccjm.92c.03005
  • You have access
    Psychedelic-assisted therapy: An overview for the internist
    Brian S. Barnett, MD, Erin E. Mauney, MD and Franklin King, MD
    Cleveland Clinic Journal of Medicine March 2025, 92 (3) 171-180; DOI: https://doi.org/10.3949/ccjm.92a.24032

    The authors review the potential effects, risks, and therapeutic applications of the psychedelic drugs MDMA (Ecstasy) and psilocybin, with a focus on MDMA-assisted therapy for posttraumatic stress disorder and psilocybin-assisted therapy for depression.

  • You have access
    Insomnia in older adults: A review of treatment options
    CME article
    Roberto León-Barriera, MD, Margaret M. Chaplin, MD, Jasleen Kaur, MD and Vania Modesto-Lowe, MD, MPH
    Cleveland Clinic Journal of Medicine January 2025, 92 (1) 43-50; DOI: https://doi.org/10.3949/ccjm.92a.24073

    Cognitive behavioral therapy for insomnia is the gold standard in all age groups, but it is time-intensive and does not offer immediate results.

  • You have access
    Sleep is like Rodney Dangerfield
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine January 2025, 92 (1) 9-10; DOI: https://doi.org/10.3949/ccjm.92b.01025

    Sleep quantity (and, in some cases, quality) has been shown to impact memory and learning, mood, appetite, and pain, yet many patients and clinicians do not give sleep the respect it deserves.

  • You have access
    Foxglove, not quite gone or forgotten
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine August 2024, 91 (8) 458-459; DOI: https://doi.org/10.3949/ccjm.91b.08024

    Digoxin use has waned dramatically over the past decades, with good reason, but for select patients, it may be a very reasonable option.

  • You have access
    Digoxin is still useful, but is still causing toxicity
    CME article
    Alejandro Durán Crane, MD, Michael Militello, PharmD, BCPS and Michael D. Faulx, MD
    Cleveland Clinic Journal of Medicine August 2024, 91 (8) 489-499; DOI: https://doi.org/10.3949/ccjm.91a.23105

    The authors review the presentation of digoxin toxicity, its mechanisms and predisposing factors, and its medical management.

  • You have access
    Reducing the risks when using benzodiazepines to treat insomnia: A public health approach
    Vania Modesto-Lowe, MD, MPH, Margaret M. Chaplin, MD, Roberto León-Barriera, MD and Lakshit Jain, MD
    Cleveland Clinic Journal of Medicine May 2024, 91 (5) 293-299; DOI: https://doi.org/10.3949/ccjm.91a.23061

    The authors review measures for preventing harm before benzodiazepines are prescribed, decreasing harm within 4 weeks after they are prescribed, and limiting harmful effects of long-term prescribing.

  • You have access
    Medical management of benign prostatic hyperplasia
    Eiftu S. Haile, MD, Ayodeji E. Sotimehin, MD and Bradley C. Gill, MD, MS
    Cleveland Clinic Journal of Medicine March 2024, 91 (3) 163-170; DOI: https://doi.org/10.3949/ccjm.91a.23027

    The goal is to maximize quality of life and minimize “bothersome” symptoms. Choices about medical therapy are guided by indication, effectiveness, side effects, as well as patient preference.

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    Should my patients take their blood pressure medications in the evening to enhance cardiovascular benefit?
    Elias Bassil, MD, George Thomas, MD, Jagmeet Dhingra, MD and Ali Mehdi, MD, MEd, FACP, FASN
    Cleveland Clinic Journal of Medicine December 2023, 90 (12) 725-727; DOI: https://doi.org/10.3949/ccjm.90a.23043

    The focus should be to achieve blood pressure control and facilitate adherence, regardless of the timing of the medications.

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