Latest Articles

  • Evolving paradigms in hypertension management: Fixed-dose single-pill combinations and future therapies
    George Thomas, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 471-474; DOI: https://doi.org/10.3949/ccjm.92a.25034

    Despite the availability of effective medications, blood pressure control rates have declined over the past decade, underscoring the need for improved treatment approaches.

  • Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation
    Anže Djordjević, MD, PhD and Edward Soltesz, MD, MPH
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 415-419; DOI: https://doi.org/10.3949/ccjm.92a.25001

    Left atrial appendage occlusion added to routine cardiac surgery reduced the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation and high stroke risk, but questions remain.

  • How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy?
    Rupayan Kundu, MD, Arjun Chatterjee, MD, Jessica Philpott, MD, PhD and Lucy Boyce Kennedy, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 401-405; DOI: https://doi.org/10.3949/ccjm.92a.24090

    Diarrhea and colitis, which can result from infection or be complications of immune checkpoint inhibitors, require prompt evaluation so that appropriate treatment can be started.

  • Fecal microbiota transplantation: Current evidence and future directions
    Fecal microbiota transplantation: Current evidence and future directions
    Michael Cymbal, DO, Arjun Chatterjee, MD and Brian Baggott, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 421-428; DOI: https://doi.org/10.3949/ccjm.92a.24107

    Fecal microbiota transplantation is recognized for effectively treating recurrent Clostridioides difficile infection, prompting further investigation into its other possible clinical applications.

  • Recreational cannabis legalization: Potential implications for individual and community health
    Taseen Alam, BA, Connor Riegal, BS, Natalie Saadeh, MD, Fernanda Gushken, MD, MS, Hannah Snyder, MD, Brenden Jenks, MD and Akhil Anand, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 407-413; DOI: https://doi.org/10.3949/ccjm.92a.24086

    The authors discuss evidence on the effects of legalized recreational cannabis on overall cannabis consumption, crime, traffic safety, and individual and community health.

  • Managing right ventricular failure in the setting of pulmonary embolism
    Anup Katyal, MD and Ashwani Joshi, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 396; DOI: https://doi.org/10.3949/ccjm.92c.07003
  • Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelines
    Oscar L. Morey-Vargas, MD, Mona Gossmann, MD, Jeffrey M. Ketz, PharmD and Basem B. Abdelmalak, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 429-437; DOI: https://doi.org/10.3949/ccjm.92a.24118

    Recommendations for adjusting the treatment regimen of each class of noninsulin glucose-lowering agents before surgery are discussed.

  • Odontogenic cutaneous fistula
    Sagar Khanna, BDS, DDS
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 399-400; DOI: https://doi.org/10.3949/ccjm.92a.24096

    A 55-year-old woman with a history of systemic lupus erythematosus and secondary Sjögren syndrome presented with a 2-year history of facial swelling and intermittent drainage from a skin lesion on her left jaw.

  • Immunotherapy meets William Shakespeare
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 390-391; DOI: https://doi.org/10.3949/ccjm.92b.07025

    Immune checkpoint inhibitors are potentially life-saving therapies that can trigger a wide range of autoimmune pathology.

  • In Reply: Managing right ventricular failure in the setting of pulmonary embolism
    Sharmeen Sorathia, MD, Anibelky Almanzar, MD, Abhishek Bhandiwad, MD and Phoo Pwint Nandar, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 396-397; DOI: https://doi.org/10.3949/ccjm.92c.07004

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