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Contributions

Fetal substantia nigra grafts

Effect on dopamine receptors in the rat corpus striatum

E. Korfali, MD, W. Douglas Knowles, PhD, Sait Uysal, MD, I. Hakk Iulus, MD and Tulin Ozmen
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 259-262;
E. Korfali
Department of Neurosurgery, Uludag University, School of Medicine, Bursa, Turkey
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W. Douglas Knowles
Departments of Brain and Vascular Research and Neurology, The Cleveland Clinic Foundation
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Sait Uysal
Department of Neurosurgery, Uludag University, School of Medicine, Bursa, Turkey
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I. Hakk Iulus
Department of Pharmacology, Uludag University, School of Medicine, Bursa, Turkey
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Tulin Ozmen
T.O. is a student at Uludag University’s School of Medicine
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ABSTRACT

Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hy-droxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7 % increase of [3H] spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25 % decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A non-significant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.

INDEX TERMS
  • Corpus Striatum
  • Receptors
  • Dopamine
  • Substantia Nigra
  • Transplantation
  • Received December 1987.
  • Revision received December 1988.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 56 (3)
Cleveland Clinic Journal of Medicine
Vol. 56, Issue 3
1 May 1989
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Fetal substantia nigra grafts
E. Korfali, W. Douglas Knowles, Sait Uysal, I. Hakk Iulus, Tulin Ozmen
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 259-262;

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Fetal substantia nigra grafts
E. Korfali, W. Douglas Knowles, Sait Uysal, I. Hakk Iulus, Tulin Ozmen
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 259-262;
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Keywords

  • Corpus Striatum
  • Receptors
  • Dopamine
  • Substantia Nigra
  • TRANSPLANTATION

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