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Review

Diabetes insipidus: Diagnosis and treatment of a complex disease

Amgad N. Makaryus, MD and Samy I. McFarlane, MD, MPH
Cleveland Clinic Journal of Medicine January 2006, 73 (1) 65-71;
Amgad N. Makaryus
North Shore University Hospital, New York University School of Medicine, Manhasset, NY
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Samy I. McFarlane
State University of New York-Downstate and Kings County Hospital Center, Brooklyn, NY
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  • For correspondence: Samy.McFarlane@downstate.edu
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ABSTRACT

Diabetes insipidus, characterized by excretion of copious volumes of dilute urine, can be life-threatening if not properly diagnosed and managed. It can be caused by two fundamentally different defects: inadequate or impaired secretion of antidiuretic hormone (ADH) from the posterior pituitary gland (neurogenic or central diabetes insipidus) or impaired or insufficient renal response to ADH (nephrogenic diabetes insipidus). The distinction is essential for effective treatment.

  • © 2006 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 73 (1)
Cleveland Clinic Journal of Medicine
Vol. 73, Issue 1
1 Jan 2006
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Diabetes insipidus: Diagnosis and treatment of a complex disease
Amgad N. Makaryus, Samy I. McFarlane
Cleveland Clinic Journal of Medicine Jan 2006, 73 (1) 65-71;

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Diabetes insipidus: Diagnosis and treatment of a complex disease
Amgad N. Makaryus, Samy I. McFarlane
Cleveland Clinic Journal of Medicine Jan 2006, 73 (1) 65-71;
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