Table of Contents

February 01, 2006; Volume 73,Issue 2

From the Editor

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A great masquerader learns a new trick
Brian F. Mandell, MD, PhD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 105;

Different generations of physicians have proposed various contenders for the title of “great masquerader.” I firmly believe that Clostridium difficile infection deserves a shot at the title.

Im Board Review

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A hypertensive emergency in an obese young woman
Raja Shekhar R. Sappati Biyyani, MD, Loren M. Kirchner, MD, MS, Anil C. Singh, MD, MPH and Prabhacharan Gill, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 110-120;

She has headache, new-onset seizures, edema, and proteinuria; her blood pressure is 235/114 mm Hg and she weighs 256 lb. What is the diagnosis?

Review

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Diagnosing and managing posttraumatic stress disorder
Kumar Budur, MD, Tatiana Falcone, MD and Kathleen Franco, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 121-129;

PTSD not only affects soldiers, it also occurs in civilians exposed to severe trauma or serious illness. Manifestations commonly include nonspecific physical symptoms, and patients often present to their primary care physician.
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Evaluating and managing hypogammaglobulinemia
Mark E. Rose, MD and David M. Lang, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 133-144;

Patients with frequent and recurrent respiratory infections should be tested for immune system abnormalities. This article describes common primary and secondary forms of hypogammaglobulinemia and how to evaluate and manage them.

Medical Grand Rounds

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Natriuretic peptide testing: A window into the diagnosis and prognosis of heart failure
James L. Januzzi, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 149-157;

BNP assays are now widely used to evaluate suspected heart failure, but they should not be the only criterion.
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Improved outcomes in nephrotic syndrome
Gerald B. Appel, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 161-167;

Nephrotic syndrome now has a dramatically different prognosis than it did 10 years ago. We can now effectively treat all types and achieve remission in many cases.

The Clinical Picture

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An expanding skin lesion in a patient on immunosuppressive therapy
Marc Williams, MD, Ravindran A. Padmanabhan, MD, MRCP (UK), Leonard H. Calabrese, DO and Steven M. Gordon, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 170-171;

The lesion, originally diagnosed as pyoderma gangrenosum, now measures 15 cm × 6 cm. What should be the next step in management?

Review

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Reviewers 2005
Cleveland Clinic Journal of Medicine February 2006, 73 (2) 175;
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Multiple sclerosis: Treating symptoms, and other general medical issues
Myla D. Goldman, MD, Jeffrey A. Cohen, MD, Robert J. Fox, MD and Francois A. Bethoux, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 177-186;

Disease-modifying therapies have been a big advance in multiple sclerosis, but many patients still experience a variety of symptoms that reduce quality of life. We have to treat the whole patient.

Departments

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Clostridium difficile-associated disease: New challenges from an established pathogen
Rebecca H. Sunenshine, MD and L. Clifford McDonald, MD

Cleveland Clinic Journal of Medicine February 2006, 73 (2) 187-197;

Clostridium difficile-associated disease (CDAD) is increasing in incidence and severity and may be becoming more difficult to treat. A new strain is causing many outbreaks.