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Article

The clinical features of PML

Joseph R. Berger, MD
Cleveland Clinic Journal of Medicine November 2011, 78 (11 suppl 2) S8-S12; DOI: https://doi.org/10.3949/ccjm.78.s2.03
Joseph R. Berger
Ruth L. Works Professor and Chairman, Department of Neurology, University of Kentucky College of Medicine, Lexington, KY
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  • For correspondence: jrbneuro@email.uky.edu
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ABSTRACT

The symptoms associated with progressive multifocal leukoencephalopathy (PML) reflect the location of pathologic brain lesions. These symptoms include visual deficits, cognitive impairment, and motor weakness; in patients with acquired immunodeficiency syndrome (AIDS), presenting signs can also include gait disturbance, dysarthria, dysphasia, and ocular palsy. Recently, PML has been observed in patients treated with biologic agents; natalizumab recipients currently represent the second largest group of patients with PML (behind patients with AIDS). Although brain biopsy is the most accurate and reliable method for diagnosing PML, it is rarely used today. Diagnosis is usually based on detection of JC virus in the cerebrospinal fluid by polymerase chain reaction, the clinical presentation, and demonstration of PML brain lesions on magnetic resonance imaging. With immune reconstitution, the prognosis of PML has improved markedly.

Footnotes

  • Dr. Berger reported that he has no financial relationships that pose a potential conflict of interest with this article.

  • © 2011 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 78 (11 suppl 2)
Cleveland Clinic Journal of Medicine
Vol. 78, Issue 11 suppl 2
1 Nov 2011
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The clinical features of PML
Joseph R. Berger
Cleveland Clinic Journal of Medicine Nov 2011, 78 (11 suppl 2) S8-S12; DOI: 10.3949/ccjm.78.s2.03

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The clinical features of PML
Joseph R. Berger
Cleveland Clinic Journal of Medicine Nov 2011, 78 (11 suppl 2) S8-S12; DOI: 10.3949/ccjm.78.s2.03
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