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Review

Paget disease of bone: Diagnosis and drug therapy

Margaret Seton, MD
Cleveland Clinic Journal of Medicine July 2013, 80 (7) 452-462; DOI: https://doi.org/10.3949/ccjm.80a.12142
Margaret Seton
Director, Metabolic Bone Diseases, and Director, Rheumatology Fellowship, Department of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital; Assistant Professor of Medicine, Harvard Medical School, Boston, MA
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ABSTRACT

Paget disease of bone is a focal disorder of aging bone that may be asymptomatic or may present with pain, bowing deformity, fracture, or a nonspecific rheumatic complaint. It is the second most common disease of bone in the elderly after osteoporosis, and the loss of structural integrity in affected bone conveys a risk of fracture. It may occur sporadically or in geographic or familial clusters. This article discusses the prevalence, pathology, workup, and treatment of Paget disease of bone.

  • Copyright © 2013 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 80 (7)
Cleveland Clinic Journal of Medicine
Vol. 80, Issue 7
1 Jul 2013
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Paget disease of bone: Diagnosis and drug therapy
Margaret Seton
Cleveland Clinic Journal of Medicine Jul 2013, 80 (7) 452-462; DOI: 10.3949/ccjm.80a.12142

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Paget disease of bone: Diagnosis and drug therapy
Margaret Seton
Cleveland Clinic Journal of Medicine Jul 2013, 80 (7) 452-462; DOI: 10.3949/ccjm.80a.12142
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