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Review

Gastric outlet obstruction: A red flag, potentially manageable

Andree H. Koop, MD, William C. Palmer, MD and Fernando F. Stancampiano, MD
Cleveland Clinic Journal of Medicine May 2019, 86 (5) 345-353; DOI: https://doi.org/10.3949/ccjm.86a.18035
Andree H. Koop
Division of Community Internal Medicine, Mayo Clinic, Jacksonville, FL
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William C. Palmer
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL
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Fernando F. Stancampiano
Division of Community Internal Medicine, Mayo Clinic, Jacksonville, FL
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    Figure 1

    Computed tomography of the abdomen in the axial plane shows gastric distention (A, arrow) and a 3.9-cm mass at the pancreatic head, with compression of the descending duodenum (B, arrow), resulting in gastric outlet obstruction. The patient, a 72-year-old woman, presented with 1 week of nausea and vomiting and was found to have pancreatic cancer. She was treated with endoscopic stenting.

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    Figure 2

    Esophagogastroduodenoscopy (A) shows a large submucosal mass in the duodenal bulb (upper arrow), with localized erosions (lower arrow). The mass was 40 × 41 mm in cross-sectional diameter on endoscopic ultrasonography. Fine-needle aspiration and pathology study revealed pancreatic adenocarcinoma. The obstruction was successfully opened (B) with a 22-mm × 12-cm WallFlex stent (Boston Scientific). The patient tolerated a liquid diet after the procedure.

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    TABLE 1

    Causes of gastric outlet obstruction

    Benign
    Peptic ulcer disease
    Nonsteroidal anti-inflammatory drug-associated stricture
    Caustic ingestion
    Postsurgical stricture or scarring
    Acute pancreatitis
    Pancreatic pseudocyst
    Annular pancreas and chronic pancreatitis
    Radiation-induced stricture
    Bezoar or foreign body
    Benign tumor (adenoma, lipoma, stromal tumor, carcinoid)
    Pancreatic heterotopia
    Crohn disease
    Eosinophilic gastroenteritis
    Tuberculosis
    Adult hypertrophic pyloric stenosis
    Amyloidosis
    Bouveret syndrome (gallstone)
    Ladd band
    Diaphragmatic hernia
    Gastric volvulus
    Percutaneous endoscopic gastrostomy tube migration
    Malignant
    Pancreatic cancer, cystic neoplasm
    Gastric cancer
    Gallbladder and bile duct cancer
    Hepatocellular carcinoma
    Ampullary cancer
    Duodenal cancer
    Gastric lymphoma (mucosa-associated lymphoid tissue)
    Metastatic disease (colon, ovary, breast, lung)
    Retroperitoneal sarcoma
    Retroperitoneal lymphadenopathy
    Gastrointestinal stromal tumor
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Cleveland Clinic Journal of Medicine: 86 (5)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 5
1 May 2019
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Gastric outlet obstruction: A red flag, potentially manageable
Andree H. Koop, William C. Palmer, Fernando F. Stancampiano
Cleveland Clinic Journal of Medicine May 2019, 86 (5) 345-353; DOI: 10.3949/ccjm.86a.18035

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Gastric outlet obstruction: A red flag, potentially manageable
Andree H. Koop, William C. Palmer, Fernando F. Stancampiano
Cleveland Clinic Journal of Medicine May 2019, 86 (5) 345-353; DOI: 10.3949/ccjm.86a.18035
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    • ABSTRACT
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    • BENIGN AND MALIGNANT CAUSES
    • PRESENTING SYMPTOMS
    • SIGNS ON EXAMINATION
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