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Review

Measles: A dangerous vaccine-preventable disease returns

Amy Porter, MD, PhD and Johanna Goldfarb, MD
Cleveland Clinic Journal of Medicine June 2019, 86 (6) 393-398; DOI: https://doi.org/10.3949/ccjm.86a.19065
Amy Porter
Fellow, Rainbow Center for Comprehensive Care, Rainbow Babies and Children’s Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH
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Johanna Goldfarb
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  • For correspondence: [email protected]
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    Figure 1

    Effect of measles vaccine on incidence of measles in the United States.

    From the US Centers for Disease Control and Prevention.

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    Figure 2

    Koplik spots arise during the viral prodrome and are critical for the clinical diagnosis of measles before the onset of rash.

    From the US Centers for Disease Control and Prevention.

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    Figure 3

    Morbilliform rash of measles.

    From the US Centers for Disease Control and Prevention.

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    TABLE 1

    Vitamin A for acute measles infection: World Health Organization recommendations

    Vitamin A once daily for 2 days, at the following doses:
     Children 12 months of age or older: 200,000 IU
     Infants 6–11 months of age: 100,000 IU
     Infants < 6 months: 50,000 IU
    Another dose is recommended 4–6 weeks after the onset of the acute infection if vitamin A deficiency is likely to be present.
    • Information from reference 5.

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    TABLE 2

    Measles, mumps, and rubella vaccination: CDC recommendations

    Patient categoryRecommendations
    Routine vaccination
    Patient with no evidence of immunity to measles, mumps, or rubella (see Table 3)Give 1 dose of measles, mumps, and rubella (MMR) vaccine
    Special situations
    Pregnancy with no evidence of immunity to rubellaMMR is contraindicated during pregnancy After pregnancy (before discharge from healthcare facility), give 1 dose of MMR
    Nonpregnant women of childbearing age with no evidence of immunity to rubellaGive 1 dose of MMR
    Human immunodeficiency virus (HIV) infection with CD4 count ≥ 200 cells/μL for at least 6 months and no evidence of immunity to measles, mumps, or rubellaGive 2-dose series of MMR at least 4 weeks apart MMR is contraindicated in HIV infection with CD4 count < 200 cells/μL
    Severe immunocompromising conditionsMMR is contraindicated
    Students in postsecondary educational institutions, international travelers, and household or close personal contacts of immunocompromised persons with no evidence of immunity to measles, mumps, or rubella1 dose MMR if previously received 1 dose MMR, or 2-dose series MMR at least 4 weeks apart if previously did not receive any MMR
    Healthcare personnel born in 1957 or later with no evidence of immunity to measles, mumps, or rubella2-dose series MMR at least 4 weeks apart for measles or mumps, or at least 1 dose MMR for rubella; if born before 1957, consider 2-dose series MMR at least 4 weeks apart for measles or mumps, or 1 dose MMR for rubella
    • From the US Centers for Disease Control and Prevention.

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    TABLE 3

    US Centers for Disease Control and Prevention criteria for evidence of immunity to measles

    At least one of the following:
    Written documentation of adequate vaccinations including 1 or more doses of measles vaccine given after 12 months of age (preschool-age children) and adults “not at high risk”
    Written documentation of 2 doses of vaccine for school-age children and adults at high risk: college students, healthcare personnel, and international travelers
    Laboratory evidence of immunity
    Laboratory confirmation of measles
    Birth before 1957
    • Information from reference 4.

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Cleveland Clinic Journal of Medicine: 86 (6)
Cleveland Clinic Journal of Medicine
Vol. 86, Issue 6
1 Jun 2019
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Measles: A dangerous vaccine-preventable disease returns
Amy Porter, Johanna Goldfarb
Cleveland Clinic Journal of Medicine Jun 2019, 86 (6) 393-398; DOI: 10.3949/ccjm.86a.19065

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Measles: A dangerous vaccine-preventable disease returns
Amy Porter, Johanna Goldfarb
Cleveland Clinic Journal of Medicine Jun 2019, 86 (6) 393-398; DOI: 10.3949/ccjm.86a.19065
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  • Article
    • ABSTRACT
    • FROM UBIQUITOUS TO ERADICATED—AND BACK
    • PRESENTATION CAN VARY
    • DIAGNOSIS MAY NEED TO BE CONFIRMED
    • COMPLICATIONS: EARLY AND LATE
    • SUPPORTIVE CARE, INFECTION CONTROL
    • CURRENT THREAT
    • RECOMMENDATIONS
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