The role of GLP-1 receptor agonists in managing type 2 diabetes

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TABLE 1

Glucagon-like peptide-1 receptor agonists approved for use in the United States

Drug	Available doses	Frequency and route	Dose approved for weight management
Exenatide	5 μg, 10 μg	Twice daily subcutaneously	Not approved
Liraglutide	0.6 mg, 1.2 mg, 1.8 mg	Once daily subcutaneously	0.6 mg once daily for 1 week, increase by 0.6 mg daily at weekly intervals to a target dose of 3 mg once daily
Exenatide extended-release	2 mg	Once weekly subcutaneously	Not approved
Dulaglutide	0.75 mg, 1.5 mg, 3 mg, 4.5 mg	Once weekly subcutaneously	Not approved
Semaglutide	0.25 mg, 0.5 mg, 1 mg, 2 mg	Once weekly	Titrate every 4 weeks: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg once weekly
Semaglutide, oral	3 mg, 7 mg, 14 mg	Once daily by mouth	Not approved
Liraglutide-insulin degludec	0.36 mg-10 U 0.5 mg-16 U	Once daily subcutaneously	Not approved
Lixisenatide-insulin glargine	5 μg-15 U 10 μg-30 U	Once daily subcutaneously	Not approved
Tirzepatide	2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg	Once weekly subcutaneously	Not approved