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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Endocrinology

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    Profound xanthomas in a young man
    Lex Leonhardt, DO and Natallia Maroz, MD
    Cleveland Clinic Journal of Medicine February 2026, 93 (2) 73-75; DOI: https://doi.org/10.3949/ccjm.93a.24093

    The patient had a history of type 2 diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia, with a fasting serum triglyceride level of 9,000 mg/dL.

  • You have access
    Xanthomas: A clue to undiagnosed lipid disorders
    Ashish Sarraju, MD
    Cleveland Clinic Journal of Medicine February 2026, 93 (2) 76-77; DOI: https://doi.org/10.3949/ccjm.93a.25116

    Given the wide availability of direct-to-consumer laboratory testing, it is reasonable to ask whether a working knowledge of xanthomas still matters for trainees and clinicians.

  • You have access
    Update on antiobesity pharmacotherapy in adults: Current and emerging options
    Farah Ziyadeh, MD, Sara Saliba, MD, RD, Dania Salih Bacha, MD, Yael Mauer, MD, MPH, Marcio L. Griebeler, MD, DABOM and Bartolome Burguera, MD, PhD
    Cleveland Clinic Journal of Medicine January 2026, 93 (1) 36-46; DOI: https://doi.org/10.3949/ccjm.93a.24112

    The authors review antiobesity medications that are currently available or under investigation and discuss how to personalize obesity treatment.

  • You have access
    Diabetes: Putting off until tomorrow what could happen today can be good
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 715-717; DOI: https://doi.org/10.3949/ccjm.92b.12025

    Prevention of beta-cell loss and preservation of endogenous insulin production have been attractive treatment prerogatives in type 1 diabetes.

  • You have access
    All menopausal hormone therapy is not alike
    Henry H. Lindner, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 721-722; DOI: https://doi.org/10.3949/ccjm.92c.12002
  • You have access
    In reply: All menopausal hormone therapy is not alike
    Samantha F. Butts, MD, MSCE
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 722; DOI: https://doi.org/10.3949/ccjm.92c.12003
  • You have access
    How can I select the right thyroid hormone formulation for my patient with hypothyroidism?
    Lea El Hage, MD and Vinni Makin, MBBS, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 745-747; DOI: https://doi.org/10.3949/ccjm.92a.25042

    Knowing the features of the available thyroid hormone formulations can provide a starting point for individualizing therapy for patients who have concerns about product formulations or remain symptomatic despite a normal thyroid-stimulating hormone level.

  • Finding the cause of severe hypokalemia: A 4-step approach
    You have access
    Finding the cause of severe hypokalemia: A 4-step approach
    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-GarcĂ­a, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 748-756; DOI: https://doi.org/10.3949/ccjm.92a.25055

    This case illustrates the approach to a group of conditions associated with hypokalemia that usually pose a diagnostic challenge.

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    Latent autoimmune diabetes in adults: Not type 1, not type 2, a little of both
    CME article
    Michelle D. Lundholm, MD and Keren Zhou, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 757-763; DOI: https://doi.org/10.3949/ccjm.92a.25069

    Latent autoimmune diabetes in adults shares features of type 1 and type 2 diabetes, often leading to misdiagnosis and a delay in starting needed insulin therapy.

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    LADA: A case for starting insulin therapy at diagnosis
    Byron J. Hoogwerf, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 764-766; DOI: https://doi.org/10.3949/ccjm.92a.25084

    The author discusses factors that support starting insulin therapy at diagnosis in all patients with latent autoimmune diabetes in adults.

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