1-Minute Consult

What is the role for terlipressin in hepatorenal syndrome?

Stephanie N. Bass, PharmD, Aanchal Kapoor, MD and Christina C. Lindenmeyer, MD
Cleveland Clinic Journal of Medicine November 2023, 90 (11) 664-667; DOI: https://doi.org/10.3949/ccjm.90a.23037

Article Figures & Data

Figures

Tables

  • TABLE 1

    Diagnostic criteria for hepatorenal syndrome with acute kidney injury

    Cirrhosis; acute liver failure; ACLF
    Increase in serum creatinine:

    • ≥ 0.3 mg/dL within 48 hours or

    • ≥ 50% from baseline according to ICA criteria and/or

    • Urinary output ≤ 0.5 mL/kg ≥ 6 hours.

    No full or partial response after at least 2 days of diuretic withdrawal and volume expansion with albumin (1 g/kg body weight per day to a maximum 100 g/day)
    Absence of shock
    No current or recent treatment with nephrotoxic drugs
    Absence of parenchymal disease as indicated by proteinuria > 500 mg/day, microhematuria and/or abnormal renal ultrasonography

    • ACLF = acute-on-chronic liver failure

    • Reprinted from J Hepatol 2019; 71(4):811–822. doi:10.1016/j.ep.2019.07.002. Angeli P, Garcia-Tsao G, Nadim MK, Parikh CR.

    • News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the International Club of Ascites (ICA) consensus document, with permission from Elsevier.

Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools

Jump to section

Subjects