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Laboratory testing for respiratory viruses for the clinician

Christopher C. Attaway, MD, MSc and Hannah Wang, MD, D(ABMM)
Cleveland Clinic Journal of Medicine September 2024, 91 (9 suppl 1) S42-S49; DOI: https://doi.org/10.3949/ccjm.91.s1.07
Christopher C. Attaway
Medical Microbiology Fellow, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH
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Hannah Wang
Medical Director, Molecular Microbiology and Virology Laboratories, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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  • Release date: September 1, 2024
  • Expiration date: August 31, 2026
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ABSTRACT

Testing for respiratory viruses has changed greatly over the past decade, owing to advances in technology, drug development, vaccine research, and a growing recognition of the importance of improving patient access. Here, we focus on the most common respiratory viruses and review preanalytic variables (eg, collection and storage) that affect test results, testing methods including nucleic acid amplification testing (NAAT), and controversies, challenges, and trends in diagnostic testing relevant to clinicians.

  • Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.
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  1. Christopher C. Attaway, MD, MSc
  1. Medical Microbiology Fellow, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH
  1. 29832-hannah-wangHannah Wang, MD, D(ABMM)⇑
  1. Medical Director, Molecular Microbiology and Virology Laboratories, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Correspondence:
    Hannah Wang, MD, D(ABMM), Medical Director, Molecular Microbiology and Virology, Department of Laboratory Medicine, LL1-2, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; wangh7{at}ccf.org

ABSTRACT

Testing for respiratory viruses has changed greatly over the past decade, owing to advances in technology, drug development, vaccine research, and a growing recognition of the importance of improving patient access. Here, we focus on the most common respiratory viruses and review preanalytic variables (eg, collection and storage) that affect test results, testing methods including nucleic acid amplification testing (NAAT), and controversies, challenges, and trends in diagnostic testing relevant to clinicians.

  • Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 91 (9 suppl 1)
Cleveland Clinic Journal of Medicine
Vol. 91, Issue 9 suppl 1
1 Sep 2024
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Laboratory testing for respiratory viruses for the clinician
Christopher C. Attaway, Hannah Wang
Cleveland Clinic Journal of Medicine Sep 2024, 91 (9 suppl 1) S42-S49; DOI: 10.3949/ccjm.91.s1.07

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Laboratory testing for respiratory viruses for the clinician
Christopher C. Attaway, Hannah Wang
Cleveland Clinic Journal of Medicine Sep 2024, 91 (9 suppl 1) S42-S49; DOI: 10.3949/ccjm.91.s1.07
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  • Article
    • ABSTRACT
    • THE USUAL CULPRITS
    • TRASH IN, TRASH OUT: PREANALYTIC VARIABLES
    • THE NEW GOLD STANDARD: NUCLEIC ACID AMPLIFICATION TESTS
    • ANTIGEN DETECTION TESTS
    • VIRAL CULTURE
    • SEROLOGIC TESTING
    • SEQUENCING-BASED TESTING
    • TESTING FOR INFECTIVITY
    • INCREASING CONVENIENCE AND ACCESS: DECENTRALIZED SPECIMEN COLLECTION AND TESTING
    • DISCLOSURES
    • Acknowledgements
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