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Laboratory testing for respiratory viruses for the clinician

Christopher C. Attaway, MD, MSc and Hannah Wang, MD, D(ABMM)
Cleveland Clinic Journal of Medicine September 2024, 91 (9 suppl 1) S42-S49; DOI: https://doi.org/10.3949/ccjm.91.s1.07
Christopher C. Attaway
Medical Microbiology Fellow, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH
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Hannah Wang
Medical Director, Molecular Microbiology and Virology Laboratories, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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    TABLE 1

    Viral causes of common respiratory syndromes

    VirusStrength of association with clinical syndrome
    Common coldCroupBronchiolitisInfluenza-like illnessPneumonia
    Influenza A or BModerateWeakWeakStrongStrong
    Respiratory syncytial virusModerateModerateStrongModerateStrong
    SARS-CoV-2ModerateWeakNegligibleStrongStrong
    Seasonal coronavirusesaModerateWeakWeakWeakWeak
    RhinovirusStrongWeakNegligibleWeakModerate
    Human metapneumovirusModerateWeakStrongWeakModerate
    Parainfluenza viruses 1–4ModerateStrongModerateWeakModerate
    AdenovirusesModerateWeakNegligibleModerateStrong
    • ↵aCoronaviruses 229E, HKU1, NL64, or OC43

    • Data from references 4–6

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Cleveland Clinic Journal of Medicine: 91 (9 suppl 1)
Cleveland Clinic Journal of Medicine
Vol. 91, Issue 9 suppl 1
1 Sep 2024
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Laboratory testing for respiratory viruses for the clinician
Christopher C. Attaway, Hannah Wang
Cleveland Clinic Journal of Medicine Sep 2024, 91 (9 suppl 1) S42-S49; DOI: 10.3949/ccjm.91.s1.07

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Laboratory testing for respiratory viruses for the clinician
Christopher C. Attaway, Hannah Wang
Cleveland Clinic Journal of Medicine Sep 2024, 91 (9 suppl 1) S42-S49; DOI: 10.3949/ccjm.91.s1.07
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  • Article
    • ABSTRACT
    • THE USUAL CULPRITS
    • TRASH IN, TRASH OUT: PREANALYTIC VARIABLES
    • THE NEW GOLD STANDARD: NUCLEIC ACID AMPLIFICATION TESTS
    • ANTIGEN DETECTION TESTS
    • VIRAL CULTURE
    • SEROLOGIC TESTING
    • SEQUENCING-BASED TESTING
    • TESTING FOR INFECTIVITY
    • INCREASING CONVENIENCE AND ACCESS: DECENTRALIZED SPECIMEN COLLECTION AND TESTING
    • DISCLOSURES
    • Acknowledgements
    • REFERENCES
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