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1-Minute Consult

Which patients with presumed acute infectious diarrhea in an outpatient setting should undergo gastrointestinal pathogen panel testing?

Brittany Jackson, MD, Sabrina Billings, MD, Dana M. Harris, MD, Jane Hata, PhD and Mary S. Hedges, MD
Cleveland Clinic Journal of Medicine February 2025, 92 (2) 83-86; DOI: https://doi.org/10.3949/ccjm.92a.24084
Brittany Jackson
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL
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  • For correspondence: [email protected]
Sabrina Billings
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL
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Dana M. Harris
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL
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Jane Hata
Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL
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Mary S. Hedges
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL
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    TABLE 1

    Organisms detected on multiplex gastrointestinal molecular panels

    Panels
    Verigene systemaxTAG panelbBiofire panelcBD Max assaysd,eBioCode panelfQIAstat-Dx panelg
    Bacteria and bacterial toxins
    Campylobacter speciesXXXXXX
    Clostridioides difficile toxins A and BXXX
    Plesiomonas shigelloidesXXX
    Salmonella speciesXXXXXX
    Yersinia enterocoliticaXXXXX
    Vibrio choleraeXXXX
    Vibrio parahaemolyticusXXXX
    Vibrio vulnificusXX
    Enteroaggregative Escherichia coliXX
    Enteropathogenic E coliXX
    Enterotoxigenic E coliXXXXX
    Shiga-like toxin–producing E coliXXXXXX
    E coli O157XXXX
    Shigella and enteroinvasive E coliXXXXXX
    Parasites
    Cryptosporidium speciesXXXXX
    Cyclospora cayetanensisXX
    Entamoeba histolyticaXXXXX
    Giardia duodenalishXXXXX
    Viruses
    Adenovirus 40/41XXXXX
    AstrovirusXX
    Norovirus genogroups I and IIXXXXXX
    RotavirusXXXXXX
    SapovirusXX
    • ↵a Diasorin. Verigene enteric pathogens test. https://us.diasorin.com/en/molecular-diagnostics/kits-reagents/verigene-enteric-pathogens-test. Accessed January 16, 2025.

    • ↵b Diasorin. xTAG gastrointestinal pathogen panel. https://us.diasorin.com/en/molecular-diagnostics/kits-reagents/xtag-gastrointestinal-pathogen-panel-gpp. Accessed January 16, 2025.

    • ↵c Biomeriéux. Biofire Filmarray gastrointestinal panel. www.biomerieux.com/us/en/our-offer/clinical-products/biofire-gastrointestinal-panel.html. Accessed January 16, 2025.

    • ↵d The BD Max Enteric assays include an enteric bacterial panel, extended enteric bacterial panel, enteric parasite panel, enteric viral panel, and an enteric viral panel that tests for only norovirus and rotavirus.

    • ↵e BD. Gastrointestinal infections portfolio. www.bd.com/en-no/products-and-solutions/solutions/gastrointestinal-infections-portfolio. Accessed January 16, 2025.

    • ↵f Applied BioCode. Gastrointestinal pathogen panel. www.apbiocode.com/products/assays/gi-panel/. Accessed January 16, 2025.

    • ↵g Quiagen. Syndromic testing for GI infections with QIAstat Dx. www.qiagen.com/us/applications/syndromic-testing/syndromic-testing-benefits/diagnosing-gastrointestinal-infections-with-qiastat-dx. Accessed January 16, 2025.

    • ↵h Also known as G lamblia or G intestinalis.

    • Based on information from assay manufacturer websitesa–c,e–g and reference 6.

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Cleveland Clinic Journal of Medicine: 92 (2)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 2
1 Feb 2025
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Which patients with presumed acute infectious diarrhea in an outpatient setting should undergo gastrointestinal pathogen panel testing?
Brittany Jackson, Sabrina Billings, Dana M. Harris, Jane Hata, Mary S. Hedges
Cleveland Clinic Journal of Medicine Feb 2025, 92 (2) 83-86; DOI: 10.3949/ccjm.92a.24084

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Which patients with presumed acute infectious diarrhea in an outpatient setting should undergo gastrointestinal pathogen panel testing?
Brittany Jackson, Sabrina Billings, Dana M. Harris, Jane Hata, Mary S. Hedges
Cleveland Clinic Journal of Medicine Feb 2025, 92 (2) 83-86; DOI: 10.3949/ccjm.92a.24084
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  • Article
    • ACUTE DIARRHEA DEFINED
    • WHAT ARE COMMON INFECTIOUS CAUSES OF ACUTE DIARRHEA?
    • CONSIDERATIONS WHEN ORDERING A GASTROINTESTINAL PATHOGEN PANEL
    • THE BOTTOM LINE
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