Latest Articles

  • ‘All that wheezes is not asthma’—a reminder that the physical examination

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195;
    • DOI: https://doi.org/10.3949/ccjm.93b.04026

    • In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

  • Finding the cause of severe hypokalemia

    Philip S. Mehler, MD and Dennis Gibson, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198;
    • DOI: https://doi.org/10.3949/ccjm.93c.04001

  • In Reply: Finding the cause of severe hypokalemia

    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198;
    • DOI: https://doi.org/10.3949/ccjm.93c.04002

  • Palatal mass with an overlying white lesion

    Takuma Watanabe, DDS, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 199-200;
    • DOI: https://doi.org/10.3949/ccjm.93a.25050

    • The patient had no symptoms related to the mass, and computed tomography did not show any notable abnormalities.

  • Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options

    Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205;
    • DOI: https://doi.org/10.3949/ccjm.93a.25052

    • In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • Treating perinatal mood and anxiety disorders: A call to action

    Lulu Zhao, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 207-209;
    • DOI: https://doi.org/10.3949/ccjm.93a.26002

    • Perinatal mood and anxiety disorders remain untreated in 3 of 4 affected individuals giving birth.

  • Clinical application of the complement system: A historical perspective

    Adam J. Brown, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239;
    • DOI: https://doi.org/10.3949/ccjm.93a.26014

    • Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • A 20-year-old woman with a 9-year history of shortness of breath

    Jack Johnson, OMS-1, Karishma Lukose, MS4 and Mary C. Labanowski, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 211-217;
    • DOI: https://doi.org/10.3949/ccjm.93a.25073

    • The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.

  • Interpreting the DIGIT-HF trial: Time for a new look at digitalis?

    Enmanuel A. Leiva-Murillo, MD, Oriol Ventosa-Blázquez, MD and Eduard Solé-González, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 218-226;
    • DOI: https://doi.org/10.3949/ccjm.93a.25098

    • Digitoxin reduced the risk of death or first hospitalization for heart failure in patients with symptomatic heart failure with reduced ejection fraction who were already being treated with guideline-directed medical therapy.

  • A 24-year-old man with severe hemolytic anemia and variable Coombs test results

    Sindu Iska, MD, María Herrán, MD, You Li, MD, Maria Teresa Bejarano, MD, Chakra P. Chaulagain, MD and Chieh-Lin Fu, MD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 159-168;
    • DOI: https://doi.org/10.3949/ccjm.93a.25079

    • The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.

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