Latest Articles

  • Hyperactive delirium in hospitalized older adults: Balancing medication choices and QTc prolongation risk

    Emily Hao, MD, Tamara Lhungay, MD, Jessica Arabi, PharmD, BCCCP, Colin J. Harrington, MD and Iva Neupane, MD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 325-330;
    • DOI: https://doi.org/10.3949/ccjm.93a.25092
    • Medications for managing delirium symptoms, particularly antipsychotics, are associated with prolongation of the QT interval, which is a risk factor for the development of fatal arrhythmias.

  • Disseminated coccidioidomycosis masquerading as bacterial cellulitis

    Santana Maria Bachaalany, DO, Nelson Nicolasora, MD, Lindsay Ackerman, MD, Ghassan Ibrahim, MD and Trent Smith, MD
    • Cleveland Clinic Journal of Medicine June 2026, 93 (6) 321-323;
    • DOI: https://doi.org/10.3949/ccjm.93a.25096
    • The patient exhibited signs of sepsis along with progressive left breast erythema, induration, and pain.

  • Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight

    CME Image
    Leandro Sierra, MD, Lily Liu, MD, Akash Khurana, MD, Roma Patel, MD, Arjun Chatterjee, MD, Stephen Firkins, MD and Roberto Simons-Linares, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286;
    • DOI: https://doi.org/10.3949/ccjm.93a.25082
    • Weight loss of at least 10% is associated with fibrosis regression in most patients, but losing this amount of weight and keeping it off is challenging, making pharmacologic and procedural interventions essential tools in clinical practice.

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    Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know

    Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 289-295;
    • DOI: https://doi.org/10.3949/ccjm.93a.26003
    • Clonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.

  • Fighting ageism: Preserving patient agency in critical care

    Astefanos Al-Dalakta, MD, Ruth Diana Lee, MD, Chadi Tabaja, MD, Issam Motairek, MD and Eduardo Mireles-Cabodevila, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 263-265;
    • DOI: https://doi.org/10.3949/ccjm.93a.25105
    • To avoid falling into ageism bias, we must maintain a framework grounded in respect for the patient, one that deliberately centers on the patient’s voice.

  • FINEARTS-HF: Improving outcomes in heart failure with preserved or mildly reduced ejection fraction

    Salman Salahuddin, MD, DM, MRCP(UK)
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 273-277;
    • DOI: https://doi.org/10.3949/ccjm.93a.25081
    • FINEARTS-HF established finerenone as an effective medical therapy to reduce hospitalizations for heart failure in patients with HFpEF or HFmrEF.

  • Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline

    Paru S. David, MD, MSCP, Hannah Nordhues, MD, MSCP and Suneela Vegunta, MD, MSCP
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 297-303;
    • DOI: https://doi.org/10.3949/ccjm.93a.25049
    • Sex-specific factors like adverse pregnancy outcomes and premature and early menopause play a critical and often underrecognized role in shaping lifetime stroke risk in women.

  • Iris roseola: A diagnostic clue in neurosyphilis

    Victor Alegre-Ituarte, MD, PhD and Elena Franz-Lacomba, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 259-260;
    • DOI: https://doi.org/10.3949/ccjm.93a.25047
    • The patient had a 3-week history of decreased vision in the left eye, with a best-corrected visual acuity of 20/100.

  • Varicella-zoster virus transmission from herpes zoster exposure

    Ayano Takeiri, MD, Kentaro Ishikura, MD and Yoshitaka Tomoda, MD, PhD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 261-262;
    • DOI: https://doi.org/10.3949/ccjm.93a.25068
    • Two weeks before the patient developed fever and a rash, his mother had developed herpes zoster on her torso.

  • Unexplained liver injury: Searching for the cause

    Mohamed Eldib, MD, William D. Carey, MD and Blazenka Skugor, MD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272;
    • DOI: https://doi.org/10.3949/ccjm.93a.25099
    • The patient presented with persistent low back pain, nausea, poor appetite, and an unintentional weight loss of more than 30 lb over the previous 6 weeks.