ABSTRACT
In 2 women who had received nitrofurantoin for two to five years, autoimmune chronic hepatitis developed, leading to sevère hepatic necrosis and, in one case, cirrhosis. Treatment consisted of withdrawal and, in one case, institution of steroids and azathioprine. Both patients demonstrated symptomatic and biochemical improvement despite chronic histological changes. Nitrofurantoin is a cause of "lupoid" chronic active hepatitis which could lead to severe and irreversible histological changes.
- Received October 1984.
- Accepted March 1985.
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