Index by author

July 01, 1993; Volume 60,Issue 4

  1. Lee, Kamthorn S.

    1. Hemopericardium and cardiac tamponade associated with warfarin therapy
      Kamthorn S. Lee, MD and Thomas Marwick, MD
      Cleveland Clinic Journal of Medicine July 1993, 60 (4) 336-338;

  2. Licata, Angelo A.

    1. From bathtub ring to osteoporosis: a clinical review of the bisphosphonates
      Angelo A. Licata, MD, PhD
      Cleveland Clinic Journal of Medicine July 1993, 60 (4) 284-290;

      BACKGROUND Etidronate and pamidronate are bisphosphonates, a class of chemical compounds originally used to soften hard water and prevent soap scum. Etidronate was serendipitously found to abate calcification in a child with myositis ossificans progressiva.

      OBJECTIVE Review the basic pharmacology of these compounds, as well as clinical uses of the approved and nonapproved forms.

      DISCUSSION Etidronate is approved for the treatment of hypercalcemia, Paget’s disease of bone, and ectopic calcification, and has been used to treat hyperparathyroidism and nephrolithiasis with limited success. Recently it has been used to treat osteoporosis. Pamidronate is approved to treat hypercalcemia. These two drugs are the only bisphosphonates available in the United States.

      CONCLUSIONS Clinical trials with etidronate have aroused widespread interest in the application of bisphosphonates to treat osteoporosis. Many trials are underway to evaluate these new drugs. More information will be available within the next 5 years.

  3. Loke, Jacob

    1. The pulmonary effects of free-base cocaine: a review
      Ira S. Meisels, MD and Jacob Loke, MD
      Cleveland Clinic Journal of Medicine July 1993, 60 (4) 325-329;

      Respiratory symptoms, pulmonary hemorrhage, pulmonary edema, asthma, pulmonary barotrauma, and other pulmonary effects of free-base cocaine are reviewed.

  4. Longworth, David L.

    1. The elevated peripheral white blood count
      Brian J. Bolwell, MD
      Cleveland Clinic Journal of Medicine July 1993, 60 (4) 267-268;
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