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Review

Management of hyponatremia: Providing treatment and avoiding harm

Chirag Vaidya, MD, Warren Ho, MD and Benjamin J. Freda, DO
Cleveland Clinic Journal of Medicine October 2010, 77 (10) 715-726; DOI: https://doi.org/10.3949/ccjm.77a.08051
Chirag Vaidya
Tufts University School of Medicine; Renal Division, Baystate Medical Center, Springfield, MA
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Warren Ho
Nephrologist/Hospitalist, Franklin Square Hospital, Baltimore, MD
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Benjamin J. Freda
Assistant Professor of Medicine, Tufts University School of Medicine, Renal Division, Baystate Medical Center, Springfield, MA
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ABSTRACT

Hyponatremia, in its most severe form, requires urgent infusion of hypertonic saline to correct cerebral edema. However, overly rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome. The authors review the treatment of hyponatremia in order to provide clinicians with a sound approach in a variety of settings in which severity, symptoms, and underlying disease states influence therapy. Also discussed is the current role of vasopressin antagonists in treatment.

  • © 2010 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 77 (10)
Cleveland Clinic Journal of Medicine
Vol. 77, Issue 10
1 Oct 2010
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Management of hyponatremia: Providing treatment and avoiding harm
Chirag Vaidya, Warren Ho, Benjamin J. Freda
Cleveland Clinic Journal of Medicine Oct 2010, 77 (10) 715-726; DOI: 10.3949/ccjm.77a.08051

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Management of hyponatremia: Providing treatment and avoiding harm
Chirag Vaidya, Warren Ho, Benjamin J. Freda
Cleveland Clinic Journal of Medicine Oct 2010, 77 (10) 715-726; DOI: 10.3949/ccjm.77a.08051
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