Table of Contents
From the Editor
- Finding the right target for treating Alzheimer disease
It is not always easy to pick a therapeutic target. Sometimes, potential targets are actually embers of the pathologic process rather than flames driving the disease.
1-Minute Consult
- Should healthy people take a multivitamin?
No. There is no scientific basis for recommending vitamin-mineral supplements to the healthy population.
Editorial
- Is there a doctor in your house? Home health care of the future
A modernized, efficient, effective home health care system would be a welcome improvement on the patchwork system we have had for the past 30 years.
Review
- Taking blood pressure: Too important to trust to humans?
The reality of blood pressure measurement is that human beings do not do it very well. The time has come to delegate this job to machines that can do it better.
Medical Grand Rounds
- Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?
Efforts to modify the course of Alzheimer disease have, until now, been based on altering the production or clearance of beta-amyloid. Results have been disappointing.
Review
- Noninvasive positive pressure ventilation for stable outpatients: CPAP and beyond
We discuss the different types of noninvasive positive pressure ventilation, the specific conditions in which they can be used, and the evidence supporting their efficacy in outpatients.
Management of hyponatremia: Providing treatment and avoiding harmUndercorrection of acute symptomatic hyponatremia can lead to serious neurologic injury, but so can overly rapid correction of chronic hyponatremia.
The Clinical Picture
- Palmoplantar eruption
A 38-year-old woman with a history of episodes of arthritis presents with pustules on the palms and on the soles of her feet. What is the most likely diagnosis?
Commentary
We may be able to improve the care of our vulnerable older patients—and control costs—by taking their primary care to their own homes.