ABSTRACT
Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.
Footnotes
↵* The author has disclosed intellectual property rights in connection with Inova Diagnostics, and consulting for and medical advisory board membership with Walgreens, Novartis, and Questcor.
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