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Review

Penicillin allergy: A practical guide for clinicians

Alexei Gonzalez-Estrada, MD and Cristine Radojicic, MD
Cleveland Clinic Journal of Medicine May 2015, 82 (5) 295-300; DOI: https://doi.org/10.3949/ccjm.82a.14111
Alexei Gonzalez-Estrada
Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic
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  • For correspondence: gonzala5@ccf.org
Cristine Radojicic
Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic
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ABSTRACT

Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as “penicillin-allergic” are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.

  • Copyright © 2015 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 82 (5)
Cleveland Clinic Journal of Medicine
Vol. 82, Issue 5
1 May 2015
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Penicillin allergy: A practical guide for clinicians
Alexei Gonzalez-Estrada, Cristine Radojicic
Cleveland Clinic Journal of Medicine May 2015, 82 (5) 295-300; DOI: 10.3949/ccjm.82a.14111

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Penicillin allergy: A practical guide for clinicians
Alexei Gonzalez-Estrada, Cristine Radojicic
Cleveland Clinic Journal of Medicine May 2015, 82 (5) 295-300; DOI: 10.3949/ccjm.82a.14111
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