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Im Board Review

Renal failure in HCV cirrhosis

Chitra Deepak Punjabi, MD, Yu Kuang Lai, MD, Manjula Balasubramanian, MD and Imara Dissanayake, MD, FACP
Cleveland Clinic Journal of Medicine August 2016, 83 (8) 583-588; DOI: https://doi.org/10.3949/ccjm.83a.15106
Chitra Deepak Punjabi
Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA
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  • For correspondence: [email protected]
Yu Kuang Lai
Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA
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Manjula Balasubramanian
Chief, Clinical Pathology, Department of Pathology, Albert Einstein Medical Center, Philadelphia, PA
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Imara Dissanayake
Department of Nephrology and Hypertension, Albert Einstein Medical Center, Philadelphia, PA
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  • FIGURE 1
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    FIGURE 1

    Pathophysiology of hepatorenal syndrome and other common associated clinical findings.

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    FIGURE 2

    Kidney biopsy showing lobular glomeruli (hematoxylin and eosin, × 40).

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    FIGURE 3

    Kidney biopsy showing glomerular basement membranes with double contours (“tram tracking”) (silver stain, × 40).

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    TABLE 1

    Our patient’s declining renal function

    Test4 months before admission2 weeks before admission3 days before admission
    Creatinine (mg/dL)1.62.43.1
    Blood urea384144
    nitrogen (mg/dL)
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    TABLE 2

    Our patient’s laboratory values on admission

    TestValueReference range
    Blood
    Sodium140 mmol/L135–146
    Potassium4.6 mmol/L3.5–5.0
    Chloride119 mmol/L98–110
    Blood urea nitrogen50 mg/dL10–25
    Creatinine3.6 mg/dL0.7–1.4
    Bicarbonate18 mmol/L23–32
    Calcium7.6 mg/dL8.5–10.5
    Alkaline phosphatase107 IU/L40–150
    Total bilirubin0.3 mg/dL0–1.5
    Direct bilirubin0.2 mg/dL0–0.4
    Albumin1.5 g/dL3.5–5.0
    Globulins4.0 g/dL
    Aspartate aminotransferase16 IU/L7–40
    Alanine aminotransferase29 IU/L5–50
    International normalized ratio1.20.8–1.2
    Urine
    Sodium28 mmol/L14–216
    Urea411 mmol/L140–1500
    Spot creatinine19020–300
    Spot protein3600–20
    Spot protein–creatinine ratio1.9< 0.2
    Fractional excretion of sodium0.4%
    Fractional excretion of urea15.6%
    Specific gravity1.0171.005–1.030
    pH6.04.5–8.0
    White blood cell count450/HPF0–5
    Red blood cell count6/HPF0–5
    Protein100 mg/dL0–20
    Ascitic fluid
    White blood cell count28/HPF
    Polymorphonuclear neutrophils7/HPF
    • HPF = high-power field

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    TABLE 3

    Results of additional testing in our patient

    TestResultReference value
    Serum cryoglobulinsNegativeNegative
    Rheumatoid factorNegativeNegative
    Complement C353.4 mg/dL82–185
    Complement C417.0 mg/dL15–53
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Cleveland Clinic Journal of Medicine: 83 (8)
Cleveland Clinic Journal of Medicine
Vol. 83, Issue 8
1 Aug 2016
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Renal failure in HCV cirrhosis
Chitra Deepak Punjabi, Yu Kuang Lai, Manjula Balasubramanian, Imara Dissanayake
Cleveland Clinic Journal of Medicine Aug 2016, 83 (8) 583-588; DOI: 10.3949/ccjm.83a.15106

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Renal failure in HCV cirrhosis
Chitra Deepak Punjabi, Yu Kuang Lai, Manjula Balasubramanian, Imara Dissanayake
Cleveland Clinic Journal of Medicine Aug 2016, 83 (8) 583-588; DOI: 10.3949/ccjm.83a.15106
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  • Article
    • EXPLORING THE CAUSE OF RENAL FAILURE
    • HISTOLOGIC FINDINGS
    • BACK TO OUR PATIENT
    • WHO SHOULD RECEIVE TREATMENT FOR HCV?
    • OUR PATIENT’S COURSE
    • REFERENCES
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