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Medical Grand Rounds

Diabetes medications and cardiovascular outcome trials: Lessons learned

Kershaw V. Patel, MD, Natalia De Albuquerque Rocha, MD and Darren K. McGuire, MD, MHSc
Cleveland Clinic Journal of Medicine October 2017, 84 (10) 759-767; DOI: https://doi.org/10.3949/ccjm.84gr.17006
Kershaw V. Patel
Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas
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Natalia De Albuquerque Rocha
Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas
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Darren K. McGuire
Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas
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    TABLE 1

    Novel diabetes drugs: Findings of cardiovascular outcome studies

    DrugFindings
    Dipeptidyl peptidase-4 inhibitors
    AlogliptinCardiovascular safety
    Heart failure caution
    LinagliptinaResults not available
    SaxagliptinCardiovascular safety
    Heart failure caution
    SitagliptinCardiovascular safety
    Glucagon-like peptide-1 receptor agonists
    AlbiglutideaResults not available
    DulaglutideaResults not available
    ExenatideaResults not available
    LiraglutidebCardiovascular benefit
    LixisenatideCardiovascular safety
    Semaglutideb,cCardiovascular benefit
    Sodium-glucose cotransporter-2 inhibitors
    CanagliflozinaCardiovascular benefit Amputation caution
    DapagliflozinaResults not available
    EmpagliflozinCardiovascular benefit
    Cardiovascular death benefit
    ErtugliflozinaResults not available
    • ↵a Cardiovascular outcomes trials ongoing.

    • ↵b Cardiovascular effects currently under review by the US Food and Drug Administration.

    • ↵c Not available in United States.

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Cleveland Clinic Journal of Medicine: 84 (10)
Cleveland Clinic Journal of Medicine
Vol. 84, Issue 10
1 Oct 2017
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Diabetes medications and cardiovascular outcome trials: Lessons learned
Kershaw V. Patel, Natalia De Albuquerque Rocha, Darren K. McGuire
Cleveland Clinic Journal of Medicine Oct 2017, 84 (10) 759-767; DOI: 10.3949/ccjm.84gr.17006

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Diabetes medications and cardiovascular outcome trials: Lessons learned
Kershaw V. Patel, Natalia De Albuquerque Rocha, Darren K. McGuire
Cleveland Clinic Journal of Medicine Oct 2017, 84 (10) 759-767; DOI: 10.3949/ccjm.84gr.17006
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  • Article
    • ABSTRACT
    • DIABETES DRUG DEVELOPMENT
    • INCRETIN MODULATORS
    • DPP-4 INHIBITORS: NOT INFERIOR TO PLACEBO
    • GLP-1 RECEPTOR AGONISTS
    • SGLT-2 INHIBITORS
    • OTHER DRUGS WITH DEVELOPMENT HALTED
    • HOW WILL THIS AFFECT DIABETES MANAGEMENT?
    • Footnotes
    • REFERENCES
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