Renal denervation: Are we on the right path?

REFERENCES

1. ↵
   1. Bhatt DL,
   2. Kandzari DE,
   3. O’Neill WW,
   4. et al
   5. SYMPLICITY HTN-3 Investigators

   . A controlled trial of renal denervation for resistant hypertension. N Engl J Med 2014; 370:1393–1401.

   OpenUrlCrossRefPubMed
2. ↵
   1. Shishehbor MH,
   2. Hammad TA,
   3. Thomas G

   . Renal denervation: what happened, and why? Cleve Clin J Med 2017; 84:681–686.

   OpenUrlAbstract/FREE Full Text
3. ↵
   1. Kearney PM,
   2. Whelton M,
   3. Reynolds K,
   4. Whelton PK,
   5. He J

   . Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365:217–223.

   OpenUrlCrossRefPubMed
4. ↵
   1. Kearney PM,
   2. Whelton M,
   3. Reynolds K,
   4. Whelton PK,
   5. He J

   . Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004; 22:11–19.

   OpenUrlCrossRefPubMed
5. ↵
   1. Calhoun DA,
   2. Jones D,
   3. Textor S,
   4. et al
   5. American Heart Association Professional Education Committee

   . Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation 2008; 117:e510–e526.

   OpenUrlAbstract/FREE Full Text
6. ↵
   1. Tsioufis C,
   2. Papademetriou V,
   3. Thomopoulos C,
   4. Stefanadis C

   . Renal denervation for sleep apnea and resistant hypertension: alternative or complementary to effective continuous positive airway pressure treatment? Hypertension 2011; 58:e191–e192.

   OpenUrl
7. ↵
   1. Calhoun DA,
   2. Jones D,
   3. Textor S,
   4. et al

   . Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 2008; 51:140–1419.

   OpenUrl
8. ↵
   1. Persell SD

   . Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension 2011; 57:1076–1080.

   OpenUrlCrossRef
9. ↵
   1. Papademetriou V,
   2. Doumas M,
   3. Tsioufis K

   . Renal sympathetic denervation for the treatment of difficult-to-control or resistant hypertension. Int J Hypertens 2011; 2011:196518.

   OpenUrlPubMed
10. ↵
    1. Doumas M,
    2. Faselis C,
    3. Papademetriou V

    . Renal sympathetic denervation in hypertension. Curr Opin Nephrol Hypertens 2011; 20:647653.

    OpenUrl
11. ↵
    1. Veterans Administration Cooperative Study Group on Antihypertensive Agents

    . Effect of treatment on morbidity in hypertension: results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967; 202:1028–1034.

    OpenUrlCrossRefPubMed
12. ↵
    1. Lewington S,
    2. Clarke R,
    3. Qizilbash N,
    4. Peto R,
    5. Collins R,
    6. Prospective Studies Collaboration

    . Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360:1903–1913.

    OpenUrlCrossRefPubMed
13. ↵
    1. Henegar JR,
    2. Zhang Y,
    3. Hata C,
    4. Narciso I,
    5. Hall ME,
    6. Hall JE

    . Catheter- based radiofrequency renal denervation: location effects on renal norepinephrine. Am J Hypertens 2015; 28:909–914.

    OpenUrlCrossRefPubMed
14. ↵
    1. Azizi M,
    2. Sapoval M,
    3. Gosse P,
    4. et al
    5. Renal Denervation for Hypertension (DENERHTN) investigators

    . Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet 2015; 385:19571965.

    OpenUrl
15. ↵
    1. Rosa J,
    2. Widimsky P,
    3. Waldauf P,
    4. et al

    . Role of adding spironolactone and renal denervation in true resistant hypertension: one-year outcomes of randomized PRAGUE-15 study. Hypertension 2016; 67:397–403.

    OpenUrl
16. ↵
    1. Mahfoud F,
    2. Bohm M,
    3. Azizi M,
    4. et al

    . Proceedings from the European Clinical Consensus Conference for Renal Denervation: Considerations on Future Clinical Trial Design. Eur Heart J 2015; 6:2219–2227.

    OpenUrl