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Absolute contraindications Acute malignancy (except nonmelanomatous skin cancer) Active human immunodeficiency virus infection (treated patients may be eligible) Other active infection (excluding hepatitis C) Chronic illness with short life expectancy Poorly controlled psychosis Acute substance abuse End-stage heart, lung, or liver disease (consider for combined transplant) Anatomic barriers precluding transplant Relative contraindications Active coronary artery disease or advanced heart failure Cirrhosis or advanced hepatic fibrosis Advanced peripheral or cerebrovascular disease Advanced age Morbid obesity Smoking Active peptic ulcer or inflammatory bowel disease Habitual noncompliance Poor psychosocial or financial situation threatening adequate posttransplant care Increase levels of cyclosporine, tacrolimus, sirolimus Clarithromycin Erythromycin Azole antifungals Diltiazem Verapamil Isoniazid Protease inhibitors Grapefruit Reduce levels of cyclosporine, tacrolimus, sirolimus Rifampin Phenytoin Carbamazepine Phenobarbital Nevirapine St. John’s wort Cytomegalovirus viremia BK virus nephropathy Epstein-Barr virus meningitis Cryptococcal meningitis Pulmonary aspergillosis Histoplasmosis Rhizopus cellulitis Strongyloides stercoralis infestation Disseminated tuberculosis West Nile virus infection Mycobacterium avium complex infection Mycobacterium szulgai pneumonia
