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Im Board Review

A 75-year-old with abdominal pain, hypoxia, and weak pulses in the left leg

Maya Serhal, MD, Natalie Evans, MD, RPVI and Heather L. Gornik, MD, RVT, RPVI
Cleveland Clinic Journal of Medicine February 2018, 85 (2) 145-154; DOI: https://doi.org/10.3949/ccjm.85a.16069
Gregory W. Rutecki
Vascular Medicine Section, Department of Cardiovascular Medicine, Cleveland Clinic
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Maya Serhal
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  • For correspondence: [email protected]
Natalie Evans
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Heather L. Gornik
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    Figure 1

    The patient’s electrocardiogram on presentation. Arrows point to notable features (see text).

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    Figure 2

    Computed tomography (CT) with a chest pulmonary embolism protocol (top) showed filling defects (arrows). CT of the abdomen and pelvis showed renal artery thrombosis (arrow).

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    Figure 3

    Example of lower-extremity duplex ultrasonography. Arteries and veins are labeled. Veins with-out deep vein thrombosis are compressible, as seen on the left. A vein is shown that is not compressible, suggesting deep vein thrombosis.

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    Figure 4

    The patient’s ankle-brachial index and pulse-volume recordings. Right side 1.24, left side 0.68. This suggests moderate disease on the left and normal vessels on the right.

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    Figure 5

    Antiphospholipid antibody tests and terminology.

    From Houghton DE, Moll S. Antiphospholipid antibodies. Vasc Med 2017; 22:545–550.

Tables

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    TABLE 1

    The patient’s laboratory data on presentation

    TestValueaReference range
    Complete blood cell count
    White blood cell count15.373.70–11.00 × 109/L
    Red blood cell count4.454.20–6.00 × 109/L
    Hemoglobin13.713.0–17.0 g/dL
    Hematocrit41.239.0%–51.0%
    Mean corpuscular volume92.680.0–100.0 fL
    Mean corpuscular hemoglobin30.826.0–34.0 pg
    Mean corpuscular hemoglobin concentration33.330.5–36.0 g/dL
    Red blood cell distribution width13.811.5%–15.0%
    Platelet count204150–400 × 109/L
    Mean platelet volume11.89.0–12.7 fL
    Complete metabolic panel
    Protein, total6.76.0–8.4 g/dL
    Albumin3.13.5–5.0 g/dL
    Calcium8.48.5–10.5 mg/dL
    Bilirubin, total0.20.0–1.5 mg/dL
    Alkaline phosphatase11840–150 U/L
    Aspartate aminotransferase707–40 U/L
    Glucose11265–100 mg/dL
    Blood urea nitrogen2410–25 mg/dL
    Creatinine1.670.70–1.40 mg/dL
    Sodium140135–146 mmol/L
    Potassium4.93.5–5.0 mmol/L
    Chloride10098–110 mmol/L
    Carbon dioxide2723–32 mmol/L
    Anion gap130–15 mmol/L
    Alanine aminotransferase575–50 U/L
    Estimated glomerular filtration rate40> 90 mL/min
    Cardiac biomarkers
    NT-proBNP11,336< 450 pg/mL
    Troponin T0.0810–0.029 ng/mL
    Creatine kinase9430–220 U/L
    Creatine kinase MB6.40.0–8.8 ng/mL
    Coagulation profile
    Activated partial thromboplastin time27.223.0–32.4 sec
    Prothrombin time10.78.4–13.0 sec
    Prothrombin time INRx1.10.8–1.2
    Urinalysis
    ColorYellowYellow
    ClaritySlightly cloudyClear
    Glucose, urineNegativeNegative
    Bilirubin, urineNegativeNegative
    KetonesNegativeNegative
    Specific gravity< 1.0051.005–1.030
    Hemoglobin/blood2+Negative
    pH5.04.5–8.0
    Protein300 mg/dL
    UribilinogenNormalNormal
    NitritesNegativeNegative
    Leukocyte esteraseNegativeNegative
    White blood cells0–50–5/high-power field
    Red blood cells6–100–3/high-power field
    • ↵a Abnormal values are shown in bold. INR = international normalized ratio; NT-proBNP = N-terminal pro-B-type natriuretic peptide

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    TABLE 2

    Classification of pulmonary embolism

    Massive
    Sustained hypotension: systolic blood pressure < 90 mm Hg for at least 15 minutes OR requiring inotropes (cannot be due to another cause)
    Pulseless
    Persistent bradycardia (≤ 40 beats per minute with signs or symptoms of shock)
    Submassive
    Systolic blood pressure ≥ 90 mm Hg
    Right ventricular dysfunction or myocardial necrosis
    Low risk
    Normal blood pressure
    Normal biomarker levels
    No right ventricular dysfunction
    • Adapted from information in reference 3.

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Cleveland Clinic Journal of Medicine: 85 (2)
Cleveland Clinic Journal of Medicine
Vol. 85, Issue 2
1 Feb 2018
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A 75-year-old with abdominal pain, hypoxia, and weak pulses in the left leg
Maya Serhal, Natalie Evans, Heather L. Gornik
Cleveland Clinic Journal of Medicine Feb 2018, 85 (2) 145-154; DOI: 10.3949/ccjm.85a.16069

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A 75-year-old with abdominal pain, hypoxia, and weak pulses in the left leg
Maya Serhal, Natalie Evans, Heather L. Gornik
Cleveland Clinic Journal of Medicine Feb 2018, 85 (2) 145-154; DOI: 10.3949/ccjm.85a.16069
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  • Article
    • PREVIOUS HOSPITALIZATION
    • CURRENT PRESENTATION
    • WHAT DOES HIS ELECTROCARDIOGRAM SHOW?
    • CLASSIFICATION OF ACUTE PULMONARY EMBOLISM
    • ULTRASONOGRAPHY FOR DIAGNOSIS OF DEEP VEIN THROMBOSIS
    • RISK STRATIFICATION IN ACUTE PULMONARY EMBOLISM
    • ASSESSING PERIPHERAL ARTERY DISEASE
    • WHAT CAN CAUSE BOTH ARTERIAL AND VENOUS THROMBOSIS?
    • ANTIPHOSPHOLIPID ANTIBODY SYNDROME
    • ANTIPHOSPHOLIPID ANTIBODIES ARE NOT ALL THE SAME
    • PARADOXICAL EMBOLISM
    • SUMMARY OF CASE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
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