Hematology

  • Blue sclera: An overlooked finding of iron deficiency
    Yasuhiro Kano, MD
    Cleveland Clinic Journal of Medicine October 2022, 89 (10) 549-550; DOI: https://doi.org/10.3949/ccjm.89a.22045

    The pathogenesis is thought to involve thinning of collagen fibers of the sclera due to iron deficiency, allowing the bluish color of the underlying uvea to become visible.

  • A 65-year-old man with melena and a blood disorder
    Monia E. Werlang, MD, Marilia L. Montenegro, MD and Bhaumik Brahmbhatt, MD, MBBS
    Cleveland Clinic Journal of Medicine October 2022, 89 (10) 573-578; DOI: https://doi.org/10.3949/ccjm.89a.20175

    The patient had chronic anemia related to primary myelofibrosis and was being treated with epoetin alfa and ruxolitinib, with blood transfusions every other week.

  • Cirrhotic coagulopathy: A rebalanced hemostasis
    Cirrhotic coagulopathy: A rebalanced hemostasis
    Achintya D. Singh, MD, MBBS, Simon R. Mucha, MD and Christina C. Lindenmeyer, MD
    Cleveland Clinic Journal of Medicine September 2022, 89 (9) 523-533; DOI: https://doi.org/10.3949/ccjm.89a.21018

    Cirrhosis affects all 3 phases of coagulation, leading to a delicate new equilibrium, easily disturbed and tipped toward either bleeding or thrombosis by acute events such as infection, renal failure, and invasive procedures.

  • Treating anemia: It’s not just the EPO
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2022, 89 (4) 174-175; DOI: https://doi.org/10.3949/ccjm.89b.04022

    Long-term effects of treatment with the new oral inhibitors of prolyl hydroxylase will need to be carefully monitored, as prolyl hydroxylase is a key structural component of diverse proteins.

  • Anemia of chronic kidney disease: Will new agents deliver on their promise?
    Anemia of chronic kidney disease: Will new agents deliver on their promise?
    Tarek Souaid, MD, Jonathan Taliercio, DO, James F. Simon, MD, MBA, Ali Mehdi, MD, MEd and Georges N. Nakhoul, MD, MEd
    Cleveland Clinic Journal of Medicine April 2022, 89 (4) 212-222; DOI: https://doi.org/10.3949/ccjm.89a.21100

    A review of the pathophysiology of anemia of chronic kidney disease, major clinical trials, and novel therapies.

  • Microangiopathic hemolytic anemia in a female patient with systemic lupus erythematosus
    Mohammad A. Sohail, MD, Peter Luong, John Sedor, MD and Roop Kaw, MD
    Cleveland Clinic Journal of Medicine March 2022, 89 (3) 130-138; DOI: https://doi.org/10.3949/ccjm.89a.21066

    Evaluation of a patient presenting with worsening swelling of the lips and legs, decreased oral intake, intermittent pleuritic chest pain, and exertional dyspnea.

  • Recurrent anemia in a patient with chronic lymphocytic leukemia
    Sassine Ghanem, MD and Jason Gonsky, MD, PhD
    Cleveland Clinic Journal of Medicine February 2022, 89 (2) 91-98; DOI: https://doi.org/10.3949/ccjm.89a.21025

    New episodes of anemia do not automatically imply disease progression, and each should be evaluated completely.

  • A painful mass in the jaw
    CME article
    Kanishka G. Patel, MD, Jasmine C. Huynh, MD, James Liu, MD, Paul Aronowitz, MD and May Cho, MD
    Cleveland Clinic Journal of Medicine January 2022, 89 (1) 27-35; DOI: https://doi.org/10.3949/ccjm.89a.20156

    The patient presented with a painful mass in the left side of her jaw, headache, lockjaw, painful swallowing, night sweats, and unintentional weight loss.

  • Sometimes the look is worth the walk
    Brian F. Mandell, MD
    Cleveland Clinic Journal of Medicine January 2022, 89 (1) 4-5; DOI: https://doi.org/10.3949/ccjm.89b.01022

    We do not routinely look at blood smears today. The need for expediency and efficiency limit the time spent on activities with a low yield for influencing care. And yet, for some conditions in some patients, going back to the basics can be clinically rewarding, and even memorable.

  • Cardiac considerations in liver transplantation
    Cardiac considerations in liver transplantation
    Vikram Sharma, MD, MD(Res), Cerise Kleb, MD, Chirag Sheth, MD, Beni Rai Verma, MD, Vardhmaan Jain, MD, Ruchi Sharma, MD, MS, Parth Parikh, MD, Jacek Cywinski, MD, K. V. Narayanan Menon, MD, FAASLD, Jamak Modaresi Esfeh, MD, Bijan Eghtesad, MD, Cristiano Quintini, MD, Teresa Diago Uso, MD, Michael Z. Y. Tong, MD, Ravi Nair, MD, Ajay Bhargava, MD and Maan Fares, MD
    Cleveland Clinic Journal of Medicine January 2022, 89 (1) 46-55; DOI: https://doi.org/10.3949/ccjm.89a.21006

    Today’s transplant patients are older and more likely to have cardiac comorbidities, and effects of advanced liver disease on the circulatory system pose challenges in perioperative management.

Pages