Hematology
- Hematologic complications after kidney and pancreas transplant in a patient with chronic myeloid leukemia
This case highlights the complex interplay linking autoimmunity, solid-organ transplant, myeloid neoplasm, and Evans syndrome.
- Management of venous thromboembolism in patients with active cancer
The authors review the presentation and diagnosis of venous thromboembolism in patients with cancer and present an approach to treatment that aims to balance the bleeding risk from anticoagulation with the risk of recurrent thrombosis.
- von Willebrand disease: A guide for the internist
The pathophysiology of von Willebrand disease, its subtypes, common presentations of each subtype, diagnostic testing, and management of clinical manifestations of the disease are reviewed.
- What are the management considerations for venous thromboembolic events in patients with cirrhosis?
The authors review the current evidence on venous thromboembolic event (VTE) risk prediction in patients with cirrhosis, as well as VTE prophylaxis and anticoagulant therapy.
- Anchors away
Before you read this, I recommend that you read the interesting article in this issue by Prakash et al, part of our Symptoms to Diagnosis series.
- Is the MTHFR gene mutation associated with thrombosis?
Clinicians should educate patients with this common polymorphism about the lack of evidence for associated thrombotic risk, and instead focus on modifiable risk factors for thrombosis.
- If a patient has cirrhosis, should I correct coagulation abnormalities before a minor invasive procedure?
Hemostatic abnormalities in cirrhosis can include thrombocytopenia, prolonged prothrombin time, prolonged activated partial thromboplastin time, elevated international normalized ratio, and decreased fibrinogen.
- Unilateral green pleural effusion in a 22-year-old woman
Chills, night sweats, palpitations, and a 5-lb weight loss, preceded by 6 months of progressive dyspnea, fatigue, and reduced exercise tolerance. What is the diagnosis?
- Late complications after allogeneic hematopoietic cell transplant: What primary care physicians can do
Cardiovascular, metabolic, endocrine, rheumatologic, orthopedic, infectious, neurologic, and cognitive complications are examined, as well as secondary malignancies, psychiatric disorders, and impairments in quality of life and sexual health.
- A 50-year-old man presents with shortness of breath
Red flags included low voltage, normal sinus rhythm, and Q waves on electrocardiography, a history of carpal tunnel syndrome, and evidence of renal dysfunction.