Hematology
Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to knowClonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.
- A 24-year-old man with severe hemolytic anemia and variable Coombs test results
The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.
- Should every patient with an unprovoked venous thromboembolism have a hypercoagulable workup?
In the absence of consensus guidelines addressing this question, an individualized approach that considers personal and family history is needed.
- Stop the clot: When is laboratory evaluation for thrombophilia warranted?
Evidence does not support routine testing for an underlying hereditary thrombophilia after an arterial or venous thrombosis. Instead, the benefits of testing must be discussed with each patient.
- Gingival overgrowth in acute monocytic leukemia
A 55-year-old man presented to the emergency department with a 2-month history of progressive gingival swelling and oral pain.
- Simultaneous hemorrhage and venous thrombosis in a patient with systemic lupus erythematosus
After undergoing hip arthroplasty, the patient had hematoma formation in the pelvis, active bleeding from the surgical site, and a prolonged activated partial thromboplastin time. Careful evaluation led to the diagnosis of an acquired bleeding disorder.
- Hematologic complications after kidney and pancreas transplant in a patient with chronic myeloid leukemia
This case highlights the complex interplay linking autoimmunity, solid-organ transplant, myeloid neoplasm, and Evans syndrome.
- Management of venous thromboembolism in patients with active cancer
The authors review the presentation and diagnosis of venous thromboembolism in patients with cancer and present an approach to treatment that aims to balance the bleeding risk from anticoagulation with the risk of recurrent thrombosis.
