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In reply: Cardiorenal syndrome

Guramrinder S. Thind, MD, Mark Loehrke, MD, FACP and Jeffrey L. Wilt, MD, FACP, FCCP
Cleveland Clinic Journal of Medicine May 2018, 85 (5) 361; DOI: https://doi.org/10.3949/ccjm.85c.05002
Guramrinder S. Thind
Western Michigan University School of Medicine, Kalamazoo
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Mark Loehrke
Western Michigan University School of Medicine, Kalamazoo
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Jeffrey L. Wilt
Western Michigan University School of Medicine, Kalamazoo
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We thank Dr. Freda for his remarks and observations. Certainly, the clinical importance of this entity and the challenge it poses to clinicians cannot be overemphasized. We concur with the overall message and reply to his specific comments:

We completely agree that clinical data-gathering is of paramount importance. This includes careful history-taking, physical examination, electronic medical record review, laboratory data review, and imaging. As discussed in our article, renal electrolytes will reveal a prerenal state in acute cardiorenal syndrome, and other causes of prerenal acute kidney injury (AKI) should be ruled out. The role of point-of-care ultrasonography (eg, to measure the size and respirophasic variation of the inferior vena cava) as a vital diagnostic tool has been well described, and we endorse it.1 Moreover, apart from snapshot values, trends are also very important. This is especially pertinent when the patient care is being transferred to a new service (eg, from hospitalist service to the critical care service). In this case, careful review of diuretic dosage, renal function trend, intake and output, and weight trend would help in the diagnosis.

Inadequate diuretic therapy is perhaps one of the most common errors made in the management of patients with acute cardiorenal syndrome. As mentioned in our article, diuretics should be correctly dosed based on the patient’s renal function. It is a common misconception that diuretics are nephrotoxic: in reality, there is no direct renal toxicity from the drug itself. Certainly, overdiuresis may lead to AKI, but this is not a valid concern in patients with acute cardiorenal syndrome, who are fluid-overloaded by definition.

Another challenging clinical scenario is when a patient is diagnosed with acute cardiorenal syndrome but renal function worsens with diuretic therapy. In our experience, this is a paradoxical situation and often stems from misinterpretation of clinical data. The most common example is diuretic underdosage leading to inadequate diuretic response. Renal function will continue to decline in these patients, as renal congestion has not yet been relieved. This reiterates the importance of paying close attention to urine output and intake-output data. When the diuretic regimen is strengthened and a robust diuretic response is achieved, renal function should improve as systemic congestion diminishes.

Acute cardiorenal syndrome stems from hemodynamic derangements, and a multidisciplinary approach may certainly lead to better outcomes. Although we described the general theme of hemodynamic disturbances, patients with acute cardiorenal syndrome may have certain unique and complex hemodynamic “phenotypes” that we did not discuss due to the limited scope of the paper. One such phenotype worth mentioning is decompensated right heart failure, as seen in patients with severe pulmonary hypertension. Acute cardiorenal syndrome due to renal congestion is often seen in these patients, but they also have certain other unique characteristics such as ventricular interdependence.2 Giving intravenous fluids to these patients not only will worsen renal function but can also cause catastrophic reduction in cardiac output and blood pressure due to worsening interventricular septal bowing. Certain treatments (eg, pulmonary vasodilators) are unique to this patient population, and these patients should hence be managed by experienced clinicians.

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REFERENCES

  1. ↵
    1. Blehar DJ,
    2. Dickman E,
    3. Gaspari R
    . Identification of congestive heart failure via respiratory variation of inferior vena cava diameter. Am J Emerg Med 2009; 27(1):71–75. doi:10.1016/j.ajem.2008.01.002
    OpenUrlCrossRefPubMed
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    1. Piazza G,
    2. Goldhaber SZ
    . The acutely decompensated right ventricle: pathways for diagnosis and management. Chest 2005 128(3):1836–1852. doi:10.1378/chest.128.3.1836
    OpenUrlCrossRefPubMed
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Cleveland Clinic Journal of Medicine: 85 (5)
Cleveland Clinic Journal of Medicine
Vol. 85, Issue 5
1 May 2018
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In reply: Cardiorenal syndrome
Guramrinder S. Thind, Mark Loehrke, Jeffrey L. Wilt
Cleveland Clinic Journal of Medicine May 2018, 85 (5) 361; DOI: 10.3949/ccjm.85c.05002

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In reply: Cardiorenal syndrome
Guramrinder S. Thind, Mark Loehrke, Jeffrey L. Wilt
Cleveland Clinic Journal of Medicine May 2018, 85 (5) 361; DOI: 10.3949/ccjm.85c.05002
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