TO THE EDITOR: I read with great interest the article “Aleukemic leukemia cutis” by Abraham et al,1 as we recently had a case of this at my institution. The case is unique and quite intriguing; however, I found the pathologic description confusing and imprecise.
The authors state, “The findings were consistent with leukemic T cells with monocytic differentiation.”1 This is based on their findings that the tumor cells expressed CD4, CD43, CD68, and lysozyme. However, the cells were negative for CD30, ALK-1, CD2, and CD3.
First, I must contest the authors’ claim that “the cells co-expressed T-cell markers (CD4 and CD43)”: CD4 and CD43 are not specific for T cells and are almost invariably seen on monocytes, especially in acute monoblastic/monocytic leukemia (AMoL; also known as M5 in the French-American-British classification system).2,3 Therefore, the immunophenotype is perfect for an AMoL, but since there was no significant blood or bone marrow involvement and it was limited to the skin, this would best fit with a myeloid sarcoma, which frequently has a monocytic immunoprofile.3,4
Additionally, this would not be a mixed-phenotype acute leukemia, T/myeloid, not otherwise specified, as that requires positivity for cytoplasmic CD3 or surface CD3, and that was conspicuously absent.5 Therefore, the appropriate workup and treatment should have essentially followed the course for acute myeloid leukemia,4 which is unclear from the present report as there is no mention of a molecular workup (eg, for FLT3 and NPM1 mutations). This would, in turn, have important treatment and prognostic implications.6
The reason for my comments is to bring to light the importance of exact pathologic diagnosis, especially when dealing with leukemia. We currently have a host of treatment options and prognostic tools for the various types of acute myeloid leukemia, but only when a clear and precise pathologic diagnosis is given.5
- Copyright © 2019 The Cleveland Clinic Foundation. All Rights Reserved.
REFERENCES
- 1↵AbrahamTN, MorawieckiP, FlischelA, AgrawalB. Aleukemic leukemia cutis. Cleve Clin J Med 2019; 86(2):85–86. doi:10.3949/ccjm.86a.18057
- 2↵XuY, McKennaRW, WilsonKS, KarandikarNJ, SchultzRA, KroftSH. Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation. Leukemia 2006; 20(7):1321–1324. doi:10.1038/sj.leu.2404242
- 3↵CroninDMP, GeorgeTI, SundramUN. An updated approach to the diagnosis of myeloid leukemia cutis. Am J Clin Pathol 2009; 132(1):101–110. doi:10.1309/AJCP6GR8BDEXPKHR
- 4↵AvniB, Koren-MichowitzM. Myeloid sarcoma: current approach and therapeutic options. Ther Adv Hematol 2011; 2(5):309–316. doi:10.1177/2040620711410774
- 5↵WeirEG, Ali Ansari-LariM, BatistaDAS, . Acute bilineal leukemia: a rare disease with poor outcome. Leukemia 2007; 21(11):2264–2270. doi:10.1038/sj.leu.2404848
- 6↵De KouchkovskyI, Abdul-HayM. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J 2016; 6(7):e441. doi:10.1038/bcj.2016.50
